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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제50권 제5호
- 발행연도
- 2020.1
- 수록면
- 303 - 312 (10page)
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초록· 키워드
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Purpose: The purpose of this study was to evaluate severe periodontitis with tooth loss as a modifiable risk factor for Alzheimer dementia (AD), vascular dementia (VaD), and mixed dementia (MD) using the National Health Insurance Service-National Health Screening Retrospective Cohort database with long-term follow-up over 14 years. Methods: Multivariate Cox hazards regression analysis was applied to a longitudinal retrospective database, which was updated in 2018, to evaluate the association between severe periodontitis with few remaining teeth and dementia after adjusting for potential risk factors, including sociodemographic factors and comorbid diseases. Results: Among 514,866 individuals in South Korea, 237,940 (46.2%) participants satisfying the inclusion criteria were selected. A total of 10,115 age- and sex-matched participants with severe periodontitis and 10,115 periodontally healthy participants were randomly selected and evenly assigned. The results showed that the risks of AD (hazard ratio [HR], 1.08), VaD (HR, 1.24), and MD (HR, 1.16) were significantly higher in patients with severe periodontitis with 1?9 remaining teeth after adjustment for sociodemographic factors, anthropomorphic measurements, lifestyle factors, and comorbidities. Conclusions: Severe periodontitis with few remaining teeth (1?9) may be considered a modifiable risk factor for the development of AD, VaD, and MD in Korean adults.
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참고문헌 (40)
참고문헌 신청
Sposato LA / 2015 / Declining incidence of stroke and dementia: coincidence or prevention opportunity? / JAMA Neurol 72:1529~1531
Sorbi S / 2012 / EFNS-ENS Guidelines on the diagnosis and management of disorders associated with dementia / Eur J Neurol 19:1159~1179
Alzheimer's Association / 2017 / Alzheimer's Association Report : 2017 Alzheimer's disease facts and figures / Alzheimers Dement 13:325~373
Hebert LE / 2013 / Alzheimer disease in the United States(2010–2050)estimated using the 2010 census / Neurology 80:1778~1783
Liu CC / 2013 / Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy / Nat Rev Neurol 9:106~118
Sorbi S / 2012 / EFNS-ENS Guidelines on the diagnosis and management of disorders associated with dementia / Eur J Neurol 19:1159~1179
Alzheimer's Association / 2017 / Alzheimer's Association Report : 2017 Alzheimer's disease facts and figures / Alzheimers Dement 13:325~373
Hebert LE / 2013 / Alzheimer disease in the United States(2010–2050)estimated using the 2010 census / Neurology 80:1778~1783
Liu CC / 2013 / Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy / Nat Rev Neurol 9:106~118
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