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논문 기본 정보

자료유형
학술저널
저자정보
Ting Zhang (Shandong University School of Stomatology) Xinwei Zhang (The Second Hospital of Anhui Medical University) Mengyun Mao (Zhejiang University School of Medicine) Jiayi Li (Shanghai Jiaotong University School of Medicine) Ting Wei (Zhejiang University School of Medicine) Huiqiang Sun (Shandong University School of Stomatology)
저널정보
대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제50권 제6호
발행연도
2020.1
수록면
392 - 405 (14page)

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Purpose: Titanium implants are widely used in the treatment of dentition defects; however, due to problems such as osseointegration failure, peri-implant bone resorption, and periimplant inflammation, their application is subject to certain restrictions. The surface modification of titanium implants can improve the implant success rate and meet the needs of clinical applications. The goal of this study was to evaluate the effect of the use of porous titanium with a chitosan/hydroxyapatite coating on osseointegration. Methods: Titanium implants with a dense core and a porous outer structure were prepared using a computer-aided design model and selective laser sintering technology, with a fabricated chitosan/hydroxyapatite composite coating on their surfaces. In vivo and in vitro experiments were used to assess osteogenesis. Results: The quasi-elastic gradient and compressive strength of porous titanium implants were observed to decrease as the porosity increased. The in vitro experiments demonstrated that, the porous titanium implants had no biological toxicity; additionally, the porous structure was shown to be superior to dense titanium with regard to facilitating the adhesion and proliferation of osteoblast-like MC3T3-E1 cells. The in vivo experimental results also showed that the porous structure was beneficial, as bone tissue could grow into the pores, thereby exhibiting good osseointegration. Conclusions: Porous titanium with a chitosan/hydroxyapatite coating promoted MC3T3-E1 cell proliferation and differentiation, and also improved osseointegration in vitro. This study has meaningful implications for research into ways of improving the surface structures of implants and promoting implant osseointegration.
#Osseointegration #Dental implants #Titanium #Biocompatible materials #Porosity

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참고문헌 (29)

참고문헌 신청
Wu SL / 2013 / Surface nano-architectures and their effects on the mechanical properties and corrosion behavior of Ti-based orthopedic implants / Surf Coat Tech 233:13~26 google schola Traini T / 2008 / Direct laser metal sintering as a new approach to fabrication of an isoelastic functionally graded material for manufacture of porous titanium dental implants / Dent Mater 24:1525~1533 google schola Cook SD / 1981 / The influence of implant elastic modulus on the stress distribution around LTI carbon and aluminum oxide dental implants / J Biomed Mater Res 15:879~887 google schola Zhao D / 2013 / Microstructure and mechanical behavior of metal injection molded Ti-Nb binary alloys as biomedical material / J Mech Behav Biomed Mater 28:171~182 google schola Nie L / 2014 / β-Type Zr-Nb-Ti biomedical materials with high plasticity and low modulus for hard tissue replacements / J Mech Behav Biomed Mater 29:1~6 google schola

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