Localized probiotic-guided pocket recolonization in the treatment of chronic periodontitis: a randomized controlled clinical trial

Vikram Kumar; Rameshwari Singhal; Pavitra Rastogi; Nand Lal; Shivani Pandey; Abbas Ali Mahdi

추천

검색

자료유형: 학술저널

저자정보: Vikram Kumar (Department of Periodontology Faculty of Dental Sciences King George's Medical University) Rameshwari Singhal (Department of Periodontology Faculty of Dental Sciences King George's Medical University) Pavitra Rastogi (Department of Periodontology Faculty of Dental Sciences King George's Medical University) Nand Lal (Department of Periodontology Faculty of Dental Sciences King George's Medical University) Shivani Pandey (Department of Periodontology Faculty of Dental Sciences King George's Medical University) Abbas Ali Mahdi (Department of Periodontology Faculty of Dental Sciences King George's Medical University)

저널정보: 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제51권 제3호

발행연도: 2021.1

수록면: 199 - 212 (14page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: This randomized clinical placebo-controlled trial was conducted to evaluate the effectiveness of Lactobacillus reuteri as a probiotic in guided pocket recolonization (GPR) for the treatment of chronic periodontitis (CP) adjunctive to scaling and root planing (SRP). Methods: Forty-eight CP patients were randomly assigned to 3 treatment groups: group 1 (SRP+placebo), group 2 (SRP+single application of probiotic), and group 3 (SRP+incremental application of probiotic). Clinical parameters were evaluated at baseline and at 8, 12, and 24 weeks, whereas biochemical parameters were measured at baseline and 12 weeks. Results: At 24 weeks, the probing pocket depth and clinical attachment level improved in all 3 groups from baseline with no significant intergroup differences; however, a statistically significant difference was observed in localized plaque and gingival scores between groups 1 and 3 (P<0.05). At 12 weeks, matrix metalloproteinase-8 (MMP-8), nitric oxide (NO), and gingipains-R (Rgps) levels improved in all 3 groups, with statistically significant differences between groups 1 and 3 for MMP-8 and NO (P<0.05), but no difference for Rgps levels. Conclusions: Within its limitations, the results of this study show that incremental 3-time application of L. reuteri as a probiotic led to improvements in clinical and biochemical parameters. This protocol can be a useful adjunct to SRP in the non-surgical management of CP.

#Gingipain cysteine endopeptidases #Matrix metalloproteinases #Nitric oxide #Periodontal pocket #Probiotics #Randomized controlled trial

참고문헌 (39)

참고문헌 신청

Cobb CM / 2002 / Clinical significance of non-surgical periodontal therapy : an evidence-based perspective of scaling and root planing / J Clin Periodontol 29(Suppl 2):6~16

Sanz M / 2008 / Innovations in non-surgical periodontal therapy: consensus report of the Sixth European Workshop on Periodontology / J Clin Periodontol 35:3~7

McNabb H / 1992 / Supragingival cleaning 3 times a week. The microbiological effects in moderately deep pockets / J Clin Periodontol 19:348~356

Westfelt E / 1998 / The effect of supragingival plaque control on the progression of advanced periodontal disease / J Clin Periodontol 25:536~541

Smiley CJ / 2015 / Systematic review and metaanalysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts / J Am Dent Assoc 146:508~524.e5

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!