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논문 기본 정보

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Akihisa Kataoka (Division of Cardiology Department of Medicine Teikyo University) Sayaka Katagiri (Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Den) Hideyuki Kawashima (Division of Cardiology Department of Medicine Teikyo University) Fukuko Nagura (Division of Cardiology Department of Medicine Teikyo University) Yugo Nara (Division of Cardiology Department of Medicine Teikyo University) Hirofumi Hioki (Division of Cardiology Department of Medicine Teikyo University) Makoto Nakashima (Division of Cardiology Department of Medicine Teikyo University) Naoki Sasaki (Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Den) Masahiro Hatasa (Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Den) Shogo Maekawa (Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Den) Yujin Ohsugi (Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Den) Takahiko Shiba (Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Den) Yusuke Watanabe (Division of Cardiology Department of Medicine Teikyo University) Tomoki Shimokawa (Department of Cardiovascular Surgery Teikyo University) Takanori Iwata (Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Dent) Ken Kozuma (Division of Cardiology Department of Medicine Teikyo University)
저널정보
대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제51권 제4호
발행연도
2021.1
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226 - 238 (13page)

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Purpose: Although several reports have described the relationship between periodontal disease and cardiovascular disease, information about the association between periodontal disease and the progression of degenerative aortic stenosis (AS) is lacking. Therefore, we performed a retrospective, single-center, pilot study to provide insight into this potential association. Methods: Data from 45 consecutive patients (19 men; median age, 83 years) with mild or moderate degenerative aortic stenosis were analyzed for a mean observation period of 3.3±1.9 years. The total amount of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis and titers of serum immunoglobulin G (IgG) against periodontal bacteria and high-sensitivity C-reactive protein (hs-CRP) were evaluated. Aortic valve area (AVA), maximal velocity (Vmax), mean pressure gradient (mean PG), and the Doppler velocity index (DVI) were evaluated. The change in each parameter per year ([ParameterLATEST?ParameterBASELINE]/Follow-up Years) was calculated from the retrospective follow-up echocardiographic data (baseline vs. the most recently collected data [latest]). Results: No correlation was found between the concentration of periodontopathic bacteria in the saliva and AS status/progression. The anti-P. gingivalis antibody titer in the serum showed a significant positive correlation with AVA and DVI. Additionally, there was a negative correlation between the anti-P. gingivalis IgG antibody titer and mean PG. The hs-CRP concentration showed positive correlations with Vmax and mean PG. Meanwhile, a negative correlation was observed between the anti-P. gingivalis IgG antibody titer and ΔAVA/year and Δmean PG/year. The hs-CRP concentration showed positive correlations with Vmax and mean PG, and it was significantly higher in patients with rapid aortic stenosis progression (ΔAVA/year <?0.1) than in their counterparts. Conclusions: Our results suggest that periodontopathic bacteria such as A. actinomycetemcomitans and P. gingivalis are not directly related to the status/progression of degenerative AS. However, inflammation and a lower immune response may be associated with disease progression.
#Aortic valve stenosis #C-reactive protein #Periodontal diseases #Porphyromonas gingivalis

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참고문헌 (33)

참고문헌 신청
Pihlstrom BL / 2005 / Periodontal diseases / Lancet 366:1809~1820 google schola Genco RJ / 2010 / Prevention : reducing the risk of CVD in patients with periodontitis / Nat Rev Cardiol 7:479~480 google schola Bahekar AA / 2007 / The prevalence and incidence of coronary heart disease is significantly increased in periodontitis : a meta-analysis / Am Heart J 154:830~837 google schola Kolenbrander PE / 2002 / Communication among oral bacteria / Microbiol Mol Biol Rev 66:486~505 google schola Katagiri S / 2009 / Multi-center intervention study on glycohemoglobin (HbA1c) and serum, high-sensitivity CRP (hs-CRP) after local anti-infectious periodontal treatment in type 2 diabetic patients with periodontal disease / Diabetes Res Clin Pract 83:308~315 google schola

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