지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 409 - 416 (8page)
이용수
초록· 키워드
오류제보하기
Background: Vitiligo is a skin depigmentation disorder, for which, repigmentation treatment with combined follicular unit extraction (FUE) graft and narrowband ultraviolet B (NBUVB) is considered superior to micro-punch graft therapy. BMP4 can induce MITF expression in Neural crest stem cells (NCSCs), and α-MSH subsequently promotes the differentiation of MITF-expressing cells along the melanocyte lineage. Objective: To investigate why FUE grafting is superior to epidermal mini grafting in promoting hair follicles (HF) melanocyte cell survival and longevity, we planned the in vitro experiments HF bulge NCSCs differentiate into melanocyte precursors under the co-treatment of BMP4 and α-MSH. Methods: Cells that migrated from the HF bulge of scalp were cultured and assessed using immunofluorescence. Transcriptome analysis was performed on RNA sequencing results. Results: Basic fibroblast growth factor promotes the proliferation and survival of NCSCs, with spontaneous differentiation into SOX10+/SOX2+ glial progenitors, but not into SOX10+/MITF+ precursor melanocytes. Both BMP4 and α-MSH promoted the differentiation into MITF-expressing cells. RNA sequencing revealed a downregulation in neuregulin- 1 (NRG1) and sermaphorin 3C (SEMA3C), and upregulation in WNT10A. Furthermore, FUE grafting had a source of reservoir melanocytes superior to mini- grafting in treatment for vitiligo. Conclusion: We obtained SOX10+/ MITF+ precursor melanocytes through an induction of differentiation along the melanocyte lineage by BMP4 and α -MSH. According to the RNA sequencing results that NRG1 and SEMA3C were downregulated and WNT10A was upregulated, we postulated that HF NCSCs differentiated into melanocyte by co-treatment of BMP4 and α-MSH. Overall, FUE grafting is a more robust and substitutive treatment option for vitiligo.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Passeron T / 2012 / Activation of the unfolded protein response in vitiligo: the missing link? / J Invest Dermatol 132:2502~2504
Ezzedine K / 2015 / Vitiligo / Lancet 386:74~84
Goldstein NB / 2018 / Repigmentation of human vitiligo skin by NBUVB is controlled by transcription of GLI1 and activation of the β-catenin pathway in the hair follicle bulge stem cells / J Invest Dermatol 138:657~668
Parsad D / 2008 / Standard guidelines of care for vitiligo surgery / Indian J Dermatol Venereol Leprol 74(Suppl):S37~S45
Kumar A / 2013 / Extracted hair follicle outer root sheath cell suspension for pigment cell restoration in vitiligo / J Cutan Aesthet Surg 6:121~125
Ezzedine K / 2015 / Vitiligo / Lancet 386:74~84
Goldstein NB / 2018 / Repigmentation of human vitiligo skin by NBUVB is controlled by transcription of GLI1 and activation of the β-catenin pathway in the hair follicle bulge stem cells / J Invest Dermatol 138:657~668
Parsad D / 2008 / Standard guidelines of care for vitiligo surgery / Indian J Dermatol Venereol Leprol 74(Suppl):S37~S45
Kumar A / 2013 / Extracted hair follicle outer root sheath cell suspension for pigment cell restoration in vitiligo / J Cutan Aesthet Surg 6:121~125
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