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논문 기본 정보

저자정보
(Center for Liquid Biopsy Kaohsiung Medical University) (Center for Liquid Biopsy Kaohsiung Medical University) (Hepatobiliary Division Department of Internal Medicine Kaohsiung Medical University Hospital) (Department of Internal Medicine Hepatitis Center Kaohsiung Medical University Hospital) (Department of Internal Medicine Hepatitis Center Kaohsiung Medical University Hospital) (Hepatobiliary Division Department of Internal Medicine Kaohsiung Medical University Hospital) (Hepatobiliary Division Department of Internal Medicine Kaohsiung Medical University Hospital) (Hepatobiliary Division Department of Internal Medicine Kaohsiung Medical University Hospital) (Hepatobiliary Division Department of Internal Medicine Kaohsiung Medical University Hospital) (Hepatobiliary Division Department of Internal Medicine Kaohsiung Medical University Hospital)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제27권 제2호
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    초록·키워드

    Background/Aims: Growth hormone (GH) is the main regulator of somatic growth, metabolism, and gender dimorphism in the liver. GH receptor (GHR) signaling in cancer is derived from a large body of evidence, although the GHR signaling pathway involved in the prognosis of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV)-related HCC, remains unclear. We aimed to explore the expression of GHR and analyze its association with clinicopathologic features and prognosis of patients with chronic hepatitis C and HCC. Methods: The expression of GHR mRNA was investigated by quantitative real-time polymerase chain reaction in paired tumors and adjacent non-tumorous (ANT) liver tissues of 200 patients with chronic hepatitis C and HCC. Western blotting and immunofluorescence assays using the HCV-infected Huh7.5.1 cell model was performed. Results: GHR mRNA was significantly lower in HCV-HCC tissues than in corresponding ANT liver tissues. GHR mRNA and protein levels also decreased in the HCV-infected Huh7.5.1 cell model. Notably, lower GHR expression was associated with age of >60 years (P=0.0111) and worse clinicopathologic characteristics, including alpha-fetoprotein >100 ng/mL (P=0.0403), cirrhosis (P=0.0075), vascular invasion (P=0.0052), pathological stage II?IV (P=0.0002), and albumin ≤4.0 g/dL (P=0.0055), which were linked with poor prognosis of HCC. Most importantly, the high incidence of recurrence and poor survival rates in patients with a low ratio of tumor/ANT GHR (≤0.1) were observed, indicating that low expression levels of GHR had great risk for development of HCC in patients with chronic hepatitis C. Conclusions: Our study demonstrates a significant down-regulation of GHR expression as a new unfavorable independent prognostic factor in patients with chronic hepatitis C and HCC.
    #Receptors #Somatotropin #Carcinoma #Hepatocellular #Hepacivirus #Recurrence #Prognosis

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