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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 121 - 128 (8page)
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Purpose: In patients with locally advanced breast cancer, neoadjuvant chemotherapy is widely used. It has a distinct advantage in the downstaging of the primary tumor and provides important information about treatment response. With its increasing usage, concerns over the appropriate management of the axilla have emerged. In this study, we compared oncological outcomes of conventional axillary lymph node dissection (ALND) over axillary sampling (AS) with radiotherapy (RT) in patients who received neoadjuvant chemotherapy. Methods: In this retrospective study, we included female patients with triple negative breast cancer (TNBC) and HER2 type breast cancer who underwent breast and axillary surgery after neoadjuvant chemotherapy between May 2011 to December 2016. A total of 89 patients’ medical records were eligible for analysis. We defined AS as removal of at least four axillary lymph nodes located near the sentinel lymph nodes without full exposure of the axillary vein, long thoracic nerve, and thoracodorsal nerve. Results: The median follow-up period was 47.00 months. The disease-free survival was 69.66 months in the AS with RT group and 69.02 months in the ALND group (p=0.280). The invasive disease-free survival was 75.16 months in the AS with RT group and 78.44 months in the ALND group (p=0.218). Conclusion: AS with radiotherapy might be a feasible surgical option in patients with TNBC and HER2 type breast cancer after neoadjuvant chemotherapy.
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참고문헌 (31)
참고문헌 신청
Mauri D / 2005 / Neoadjuvant versus adjuvant systemic treatment in breast cancer : a meta-analysis / J Natl Cancer Inst 97:188~194
Jones RL / 2006 / Neoadjuvant treatment for early-stage breast cancer : opportunities to assess tumour response / Lancet Oncol 7:869~874
Giuliano AE / 2012 / Should ACOSOG Z0011 change practice with respect to axillary lymph node dissection for a positive sentinel lymph node biopsy in breast cancer / Clin Exp Metastasis 29:687~692
Vila J / 2016 / Nomograms for predicting axillary response to neoadjuvant chemotherapy in clinically node-positive patients with breast cancer / Ann Surg Oncol 23:3501~3509
Bilimoria KY / 2009 / Comparison of sentinel lymph node biopsy alone and completion axillary lymph node dissection for node-positive breast cancer / J Clin Oncol 27:2946~2953
Jones RL / 2006 / Neoadjuvant treatment for early-stage breast cancer : opportunities to assess tumour response / Lancet Oncol 7:869~874
Giuliano AE / 2012 / Should ACOSOG Z0011 change practice with respect to axillary lymph node dissection for a positive sentinel lymph node biopsy in breast cancer / Clin Exp Metastasis 29:687~692
Vila J / 2016 / Nomograms for predicting axillary response to neoadjuvant chemotherapy in clinically node-positive patients with breast cancer / Ann Surg Oncol 23:3501~3509
Bilimoria KY / 2009 / Comparison of sentinel lymph node biopsy alone and completion axillary lymph node dissection for node-positive breast cancer / J Clin Oncol 27:2946~2953
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Controversial Issues in Axillary Management after Neoadjuvant Chemotherapy
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Use of Sentinel Lymph Node Biopsy after Neoadjuvant Chemotherapy in Patients with Axillary Node-Positive Breast Cancer in Diagnosis
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The Role of Neoadjuvant Chemotherapy in Patients with ER Positive and HER2 Negative Breast Cancer
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Omission of axillary lymph node dissection in patients who underwent total mastectomy with 1 or 2 metastatic lymph nodes
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The Optimal Treatment Strategy in Hormone Receptor-positive, Human Epidermal Growth Factor Receptor 2-negative Breast Cancer Patients with 1-2 Suspicious Axillary Lymph Node on Breast MRI: Upfront Surgery vs.Neoadjuvant Chemotherapy?
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Differences in prognosis by p53 expression after neoadjuvant chemotherapy in triple-negative breast cancer
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Nomogram for accurate prediction of breast and axillary pathologic response after neoadjuvant chemotherapy in node positive patients with breast cancer
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Predictive and Prognostic Roles of Pathological Indicators for Patients with Breast Cancer on Neoadjuvant Chemotherapy
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[Breast] MRI in the Prediction of Pathological Complete Response in Breast Cancer Patients after Neoadjuvant Chemotherapy
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