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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Herein, we first time used the gum Moringa oleifera as reducing and capping agent for successful synthesis of silver nitrate and zinc oxide nanoparticles(NPs) through green synthesis approach. This study was aimed to check antibacterial activities of synthesized NPs against multidrug resistant bacteria methicillin-resistant Staphylococcus aureus (MRSA). Methods: Aqueous solutions of AgNO3 and purified gum powder were mixed with 1:1 ratio, autoclaved at 120oC for 2 min. NPs pellet collected after centrifugation at 10,000 g for 20 min. ZnO NPs were prepared by mixing purified gum powder and metal salt with1:1 ratio, heated (70oC) and stirred at 100 rpm for 4 h followed by centrifugation at 10,000 g for 20 min. Pellet was washed and calcinated at 400oC for 4 h. Antibacterial potential against E. coli, S. aureus and methicillin-resistant Staphylococcus aureus (MRSA) was assessed by widely used Kirby- Bauer antibiotic susceptibility test. Results: Optical observation of colour change from transparent to dark and UV-Visible analysis confirmed the synthesis of NPs. Fourier transform infrared spectroscopy (FTIR) of prepared nonmaterial revealed the characteristic AgNPs and ZnO stretch vibrations at wave number of 523 cm? 1 and 471 cm? 1resectively. Crystalline nature of AgNPs and ZnO NPs was confirmed by x-ray diffraction pattern with clear sharp Peaks. Scanning electron microscopy (SEM) revealed good surface morphology of AgNPs and ZnO NPs with 50nm and 60nm size respectively. AgNPs and ZnO NPs exhibited excellent antibacterial activity against E. coli (with zone of inhibition of 21 ± 02mm and 22 ± 03mm) and S.aureus ( with zone of inhibition of 20 ± 03mm and 21 ± 02mm) while good activity was observed against “super bug” methicillin-resistant Staphylococcus aureus (MRSA) with 16 ± 03mm ad 17 ± 02mm zone if inhibitions respectively. Conclusions: This novel addition of Moringa Gum based nanoparticles will open new dimensions in the field of nanomedicine and pharmaceutics especially against MDR bacterial strains.
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참고문헌 (33)
참고문헌 신청
Carnachan SM / 2019 / Polysaccharides from New Zealand Native Plants : A Review of Their Structure, Properties, and Potential Applications / Plants 8(6):163
Kpodo F / 2019 / Structure and physicochemical properties of Ghanaian grewia gum / Int J Biol Macromol 122:866~872
Anwar F / 2007 / Moringa oleifera : a food plant with multiple medicinal uses / Phytotherapy Research : An International Journal Devoted to Pharmacological Toxicological Evaluation of Natural Product Derivatives 21(1):17~25
Quelemes PV / 2013 / Development and antibacterial activity of cashew gumbased silver nanoparticles / Int J Mol Sci 14(3):4969~4981
Kora AJ / 2012 / Aqueous extract of gum olibanum(Boswellia serrata) : a reductant and stabilizer for the biosynthesis of antibacterial silver nanoparticles / Process Biochem 47(10):1516~1520
Kpodo F / 2019 / Structure and physicochemical properties of Ghanaian grewia gum / Int J Biol Macromol 122:866~872
Anwar F / 2007 / Moringa oleifera : a food plant with multiple medicinal uses / Phytotherapy Research : An International Journal Devoted to Pharmacological Toxicological Evaluation of Natural Product Derivatives 21(1):17~25
Quelemes PV / 2013 / Development and antibacterial activity of cashew gumbased silver nanoparticles / Int J Mol Sci 14(3):4969~4981
Kora AJ / 2012 / Aqueous extract of gum olibanum(Boswellia serrata) : a reductant and stabilizer for the biosynthesis of antibacterial silver nanoparticles / Process Biochem 47(10):1516~1520
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