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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 137 - 148 (12page)
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Purpose: In organ transplantation, the need for immune modulation rather than immune suppression has been emphasized. Inthis study, we investigated whether combinatorial treatments of with thalidomide (TM) and dexamethasone (DX) might be newapproaches to induce systemic immunomodulation on T cells and other immune cells that regulate the expression of co-inhibitorymolecules. Materials and Methods: Naive splenic T cells from C57BL/6 mice were sort-purified and cultured in vitro for CD4+ T cell proliferationand regulatory T cell (Treg) conversion in the presence of TM or/and DX. Expression of cytotoxic T-lymphocyte-associatedantigen-4 (CTLA-4) and programmed death-1 (PD-1) in proliferated and converted T cells was quantified by flow cytometry. Wealso quantified in vivo expression of CTLA-4 and PD-1 on splenic CD4+ T cells and other immune cells isolated from TM- or/andDX-treated mice. Mixed lymphocytes reactions (MLR) were performed to evaluate the capacity of immune cells in carrying outimmune responses. Results: CTLA-4 expressions in effector T cells in vivo and in Tregs in vivo/vitro significantly increased upon TM/DX combinatorialtreatment. Corresponding to increased CTLA-4 expression in T cells, the expression of ligand molecules for CTLA-4 significantlyincreased in splenic dendritic cells in TM/DX-treated groups. In addition, MLR results demonstrated that splenocytes isolatedfrom TM/DX-treated mice significantly suppressed the proliferation of T cells isolated from other strains. Conclusion: Based on these results, we suggest that TM/DX combinatorial treatments might be efficient immunomodulatorymethods for regulating T cell immunity.
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참고문헌 (46)
참고문헌 신청
Gillett NA / 2000 / Applications of immunohistochemistry in the evaluation of immunosuppressive agents / Hum Exp Toxicol 19:251~254
Tsuda K / 2012 / Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naive T cells into cytokineproducing mature T cells / PLoS One 7:e31465
Chakkera HA / 2017 / Negative cardiovascular consequences of small molecule immunosuppressants / Clin Pharmacol Ther 102:269~276
Humbert P / 2019 / Immune modulation by transplanted calcium phosphate biomaterials and human mesenchymal stromal cells in bone regeneration / Front Immunol 10:663
Navegantes KC / 2017 / Immune modulation of some autoimmune diseases : the critical role of macrophages and neutrophils in the innate and adaptive immunity / J Transl Med 15:36
Tsuda K / 2012 / Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naive T cells into cytokineproducing mature T cells / PLoS One 7:e31465
Chakkera HA / 2017 / Negative cardiovascular consequences of small molecule immunosuppressants / Clin Pharmacol Ther 102:269~276
Humbert P / 2019 / Immune modulation by transplanted calcium phosphate biomaterials and human mesenchymal stromal cells in bone regeneration / Front Immunol 10:663
Navegantes KC / 2017 / Immune modulation of some autoimmune diseases : the critical role of macrophages and neutrophils in the innate and adaptive immunity / J Transl Med 15:36
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