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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 622 - 630 (9page)
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초록· 키워드
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Purpose: Expression of organic anion transporting polypeptides (OATPs) 1B1/1B3 in hepatocellular carcinoma (HCC) induces aparadoxical enhancement of gadoxetic acid on liver magnetic resonance imaging (MRI). We examined the expression profile ofOATPs with regard to tumor differentiation in a genetically modified H-Ras 12V mouse model of spontaneous HCC that undergoesmultistep hepatocarcinogenesis with minimal inter-individual variation. Materials and Methods: Tumor nodules were harvested from transgenic H-Ras 12V mice. Hematoxylin and eosin-stained slideswere examined for tumor differentiation and high-grade pathological components (tumor necrosis, thickened trabeculae, or vascularinvasion). Immunohistochemistry of OATP 1B1/1B3 was performed, and OATP expression was assessed. Results: We examined well-differentiated HCCs (n=59) in which high-grade pathological components were absent (n=49) or present(n=10). Among the well-differentiated HCCs without high-grade pathological components (n=49), OATP expression was negative,weak positive, and moderate positive in 23, 17, and nine cases, respectively. Among the well-differentiated HCCs with highgradepathological components (n=10), OATP expression was negative, weak positive, and moderate positive in one, two, andseven cases, respectively. The ratio of positive OATP 1B1/1B3 expressing tumors was higher in HCCs with high-grade pathologicalcomponents than in those without high-grade pathological components (p=0.004). Conclusion: Our findings support those of previous clinical studies that have reported the frequent appearance of gadoxetic acidenhancedMRI in moderately differentiated HCC.
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참고문헌 (38)
참고문헌 신청
Van Beers BE / 2012 / Primovist, Eovist: what to expect? / J Hepatol 57:421~429
Bartolozzi C / 2007 / Biliary and reticuloendothelial impairment in hepatocarcinogenesis : the diagnostic role of tissue-specific MR contrast media / Eur Radiol 17:2519~2530
Leonhardt M / 2010 / Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA : role of human organic anion transporters / Drug Metab Dispos 38:1024~1028
Huppertz A / 2004 / Improved detection of focal liver lesions at MR imaging : multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings / Radiology 230:266~275
Choi JY / 2014 / CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part I. Development, growth, and spread: key pathologic and imaging aspects / Radiology 272:635~654
Bartolozzi C / 2007 / Biliary and reticuloendothelial impairment in hepatocarcinogenesis : the diagnostic role of tissue-specific MR contrast media / Eur Radiol 17:2519~2530
Leonhardt M / 2010 / Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA : role of human organic anion transporters / Drug Metab Dispos 38:1024~1028
Huppertz A / 2004 / Improved detection of focal liver lesions at MR imaging : multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings / Radiology 230:266~275
Choi JY / 2014 / CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part I. Development, growth, and spread: key pathologic and imaging aspects / Radiology 272:635~654
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