Anthelmintic and Analgesic Activities of Trachyspermum Khasianum H. Wolff

Innocent Sutnga; Balari Marbaniang; Gautom Hazarika; Priyanka Goswami; Ananta Choudhury

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자료유형: 학술저널

저자정보: Innocent Sutnga (Faculty of Pharmaceutical Science Assam Down Town University) Balari Marbaniang (Faculty of Pharmaceutical Science Assam Down Town University) Gautom Hazarika (Faculty of Pharmaceutical Science Assam Down Town University) Priyanka Goswami (Faculty of Pharmaceutical Science Assam Down Town University) Ananta Choudhury (Faculty of Pharmaceutical Science Assam Down Town University)

저널정보: 대한약침학회 Journal of Pharmacopuncture Journal of Pharmacopuncture 제23권 제4호

발행연도: 2020.1

수록면: 230 - 236 (7page)

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Objectives: Trachyspermum khasianum H. Wolff is a rare medicinal plant characteristical-ly used by the traditional healers in traditional medicine for the treatment of throat-pain, toothache, and stomach ache. The study was designed to determine the anthelmintic and analgesic properties of the aerial parts of Trachyspermum khasianum H. Wolff (Family:Apiaceae). The aqueous and ethanol extract of T. khasianum H. Wolff was prepared and subjected for evaluation to determine the possible therapeutic effects. Methods: Anthelmintic activities of the extracts were determined by observing the time taken to paralyze and the time taken for the death of earthworms (Eisenia foetida) as compared to the standard drug?Albendazole (20 mg/ml) and control. Analgesic potential of the extracts was evaluated using Eddy’s hot plate method to understand the analgesic activity in rats (Wistar rats) at 100 mg/kg and 200 mg/kg body weight doses and com-pared with the standard reference (Diclofenac sodium: 10 mg/kg of animals). Results: The extracts showed a significant dose-dependent anthelmintic effect at the dif-ferent concentrations (10, 20, and 40) mg/ml, compared to that of the standard drug (20 mg/ml). Also, the results suggested that the plant extracts possess significantly analgesic activity in rats. Conclusion: The studies indicate that Trachyspermum khasianum shows anthelmintic andpotent analgesic activities. Further research should be carried out to identify the specific phytoconstituents responsible for both analgesic and anthelmintic activities and its pos-sible mechanism of action.

#albendazole #analgesic #anthelmintic #diclofenac sodium #trachyspermum kha-sianum

참고문헌 (32)

참고문헌 신청

Dwivedi SN / 2012 / Phytochemistry, pharmacological studies and traditional benefits of Trachyspermum ammi (Linn.) Sprague / Int J Pharm Life Sci 3(5):1705~1709

Singh RK / 2015 / Lectotypification of four species of Indian Trachyspermum(Apiaceae) / Telopea J Plant Syst 18:247~253

Goswami P / 2017 / Pharmacognostical and preliminary phytochemical screening of leave of Polygonum muricatum / Int J Res Pharm Pharm Sci 2(3):6~10

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Nisha Raj RS / 2012 / Pharmacognostic and physicochemical analysis on the leaves of Brunfelsia americana L / Asian Pac J Trop Biomed 2(Suppl 1):S305~S307

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