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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 47 - 53 (7page)
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Purpose: This study evaluated the rate and predictors of bacteriuria in patients who underwent transurethral resection of bladder tumor (TURBT) and Bacillus Calmette-Guerin (BCG) treatment.Materials and Methods: We prospectively evaluated 266 patients who underwent TURBT and intravesical BCG treatment between January 2017 and September 2019. Urinalysis and urine culture were performed at the baseline, one to two weeks after TURBT and weekly during the BCG treatment period. The primary outcomes were the bacteriuria rates in BCG-treated patients, while the secondary outcomes were the risk factors of bacteriuria during BCG treatments. Results: Of the 266 patients, the rate of bacteriuria was 4.5% before TURBT, 5.3% in the postoperative period, and 24.4% in the BCG treatment period. After BCG instillation, urinalysis showed that 204 and 38 patients tested positive for pyuria and nitrite, respectively. Multivariate analysis indicated that the risk factors associated with bacteriuria during BCG treatment included age (odds ratio [OR]: 1.06; p=0.003), sex (female) (OR, 5.41; p=0.007), diabetes mellitus (DM) (OR, 2.82; p=0.023), postoperative bacteriuria (OR, 8.08; p=0.032), bacterial counts>100/?l in urine flow cytometry (OR, 29.72; p<0.001), and positive urine nitrite test (OR, 6.20; p=0.001) at the time of positive urine culture sampling. Conclusions: Approximately 25% of the patients suffered from bacteriuria during intravesical BCG treatment. Old age, female sex, DM, and postoperative bacteriuria were found to be the risk factors of bacteriuria during BCG treatment. Predictive factors could aid in clinical decisions during BCG treatments as well as decisions on BCG discontinuation.
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참고문헌 (17)
참고문헌 신청
DeGeorge KC / 2017 / Bladder cancer : diagnosis and treatment / Am Fam Physician 96:507~514
Haresh KP / 2007 / A prospective study evaluating surgery and chemo radiation in muscle invasive bladder cancer / J Cancer Res Ther 3:81~85
Babjuk M / 2017 / EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder : update 2016 / Eur Urol 71:447~461
Novotny V / 2016 / Impact of adjuvant intravesical bacillus Calmette-Guerin treatment on patients with high-grade T1 bladder cancer / Urol Int 96:136~141
Brausi M / 2014 / Side effects of Bacillus Calmette-Guerin (BCG) in the treatment of intermediate- and high-risk Ta, T1 papillary carcinoma of the bladder: results of the EORTC genito-urinary cancers group randomised phase 3 study comparing one-third dose with full dose and 1 year with 3 years of maintenance BCG / Eur Urol 65:69~76
Haresh KP / 2007 / A prospective study evaluating surgery and chemo radiation in muscle invasive bladder cancer / J Cancer Res Ther 3:81~85
Babjuk M / 2017 / EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder : update 2016 / Eur Urol 71:447~461
Novotny V / 2016 / Impact of adjuvant intravesical bacillus Calmette-Guerin treatment on patients with high-grade T1 bladder cancer / Urol Int 96:136~141
Brausi M / 2014 / Side effects of Bacillus Calmette-Guerin (BCG) in the treatment of intermediate- and high-risk Ta, T1 papillary carcinoma of the bladder: results of the EORTC genito-urinary cancers group randomised phase 3 study comparing one-third dose with full dose and 1 year with 3 years of maintenance BCG / Eur Urol 65:69~76
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