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논문 기본 정보

자료유형
학술저널
저자정보
Choi Young Hoon (Department of Internal Medicine and Liver Research Institute Seoul National University Hospital Seo) Lee Sang Hyub (Department of Internal Medicine and Liver Research Institute Seoul National University Hospital Seo) You Min Su (Department of Internal Medicine and Liver Research Institute Seoul National University Hospital Seo) Shin Bang Sup (Department of Internal Medicine and Liver Research Institute Seoul National University Hospital Seo) Paik Woo Hyun (Department of Internal Medicine and Liver Research Institute Seoul National University Hospital Seo) Ryu Ji Kon (Department of Internal Medicine and Liver Research Institute Seoul National University Hospital Seo) Kim Yong-Tae (Department of Internal Medicine and Liver Research Institute Seoul National University Hospital Seo) Kwon Wooil (Department of Surgery Seoul National University Hospital Seoul National University College of Medic) Jang Jin-Young (Department of Surgery Seoul National University Hospital Seoul National University College of Medic) Kim Sun-Whe (Department of Surgery Seoul National University Hospital Seoul National University College of Medic)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제2호
발행연도
2021.1
수록면
315 - 323 (9page)

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Background/Aims: There has been growing evidence on the utility of neoadjuvant FOLFIRINOX in borderline resectable (BR) or locally advanced (LA) pancreatic cancer. However, factors predicting survival in these patients remain to be identified, and we aimed to identify these prognostic factors. Methods: Between January 2013 and April 2017, patients with BR or LA pancreatic cancer who received FOLFIRINOX as their initial treatment were identified. Demographic data and clinical outcomes, including the chemotherapy response, conversion to resection, and survival, were reviewed. Results: A total of 117 patients with BR (n=39) or LA (n=78) pancreatic cancer were included. Of these patients, 29 (24.8%) underwent curative surgery, and R0 resection was achieved in 21 patients (72.4%). The median progression-free survival and overall survival time of all patients were 11.6 and 19.0 months, respectively. In resected patients, the median relapse-free survival and overall survival times were 14.8 and 28.6 months, respectively. In the multivariate Cox model, the lowest level of serum carbohydrate antigen 19-9 (CA 19-9) and resection after FOLFIRINOX were independent factors for improved overall survival. In the subgroup analysis of patients with initial 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) images, the maximum standardized uptake value (SUVmax) of the pancreatic mass was also shown as an independent factor for improved overall survival. Conclusions: In patients with BR or LA pancreatic cancer, FOLFIRINOX is a valuable neoadjuvant treatment that enables curative surgery in approximately one-quarter of patients and significantly improves overall survival. In these patients, the prognosis can be estimated using the lowest level of serum CA 19-9, operative status, and initial FDG-PET SUVmax.
#Pancreatic neoplasms #Neoadjuvant therapy #FOLFIRINOX #Survival #Prognosis

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참고문헌 (30)

참고문헌 신청
Siegel RL / 2017 / Cancer Statistics, 2017 / CA Cancer J Clin 67:7~30 google schola Heinemann V / 2008 / Perioperative management of pancreatic cancer / Ann Oncol 19(Suppl 7):vii273~vii278 google schola Stathis A / 2010 / Advanced pancreatic carcinoma : current treatment and future challenges / Nat Rev Clin Oncol 7:163~172 google schola Ryan DP / 2014 / Pancreatic adenocarcinoma / N Engl J Med 371:1039~1049 google schola Versteijne E / 2018 / Meta-analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer / Br J Surg 105:946~958 google schola

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