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논문 기본 정보

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학술저널
저자정보
Huang Shang-Chin (Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei) Su Hau-Jyun (Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei) Kao Jia-Horng (Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei) Tseng Tai-Chung (Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei) Yang Hung-Chih (Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei) Su Tung-Hung (Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei) Chen Pei-Jer (Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei) Liu Chun-Jen (Department of Internal Medicine National Taiwan University College of Medicine and Hospital Taipei)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제3호
발행연도
2021.1
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451 - 458 (8page)

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Background/Aims: Fatty liver disease is defined as a cluster of diseases with heterogeneous etiologies, and its definition continues to evolve. The novel conceptional criteria for metabolic dysfunction-associated fatty liver disease (MAFLD) were proposed in 2020 to avoid the exclusion of a certain subpopulation, but their evaluations have been limited. We aimed to examine and compare the clinical as well as histologic features of MAFLD versus nonalcoholic fatty liver disease (NAFLD) in patients with biopsy-proven hepatic steatosis. Methods: From January 2009 to December 2019, 175 patients with histology-proven hepatic steatosis and 10 with cryptogenic cirrhosis who were treated at National Taiwan University Hospital, Taipei, Taiwan, were enrolled. Patients were classified into different groups according to the diagnostic criteria of MAFLD and NAFLD. The clinical and histologic features were then analyzed and compared. Results: In total, 76 patients (41.1%) were diagnosed with both MAFLD and NAFLD, 81 patients (43.8%) were diagnosed with MAFLD alone, nine patients (4.9%) were diagnosed with NAFLD alone, and 19 patients (10.3%) were diagnosed with neither. Those with MAFLD alone exhibited a higher degree of disease severity regarding histology and laboratory data than those with NAFLD alone. Advanced fibrosis was associated with the presences of hepatitis B virus infection and metabolic diseases. Conclusions: The novel diagnostic criteria for MAFLD include an additional 38.9% of patients with hepatic steatosis and can better help identify those with a high degree of disease severity for early intervention than can the previous NAFLD criteria.
#Metabolic dysfunction-associated fatty liver disease #Nonalcoholic fatty liver disease #Metabolic diseases #Hepatic fibrosis #Hepatitis B

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참고문헌 (25)

참고문헌 신청
Younossi ZM / 2011 / Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008 / Clin Gastroenterol Hepatol 9:524~530 google schola Fan JG / 2017 / New trends on obesity and NAFLD in Asia / J Hepatol 67:862~873 google schola European Association for the Study of the Liver (EASL) / 2016 / EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease / J Hepatol 64:1388~1402 google schola Wong VW / 2018 / Asia-Pacific Working Party on Non-alcoholic Fatty Liver Disease guidelines 2017-Part 1 : Definition, risk factors and assessment / J Gastroenterol Hepatol 33:70~85 google schola Siddiqui MS / 2018 / Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science / Hepatology 67:2001~2012 google schola

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