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논문 기본 정보

자료유형
학술저널
저자정보
Lee Joon Seop (Department of Internal Medicine School of Medicine Kyungpook National University Kyungpook National) Kim Eun Soo (Department of Internal Medicine School of Medicine Kyungpook National University Kyungpook National) Cho Kwang Bum (Department of Internal Medicine Keimyung University School of Medicine Daegu Korea) Park Kyung Sik (Department of Internal Medicine Keimyung University School of Medicine Daegu Korea) Lee Yoo Jin (Department of Internal Medicine Keimyung University School of Medicine Daegu Korea) Lee Ju Yup (Department of Internal Medicine Keimyung University School of Medicine Daegu Korea)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제4호
발행연도
2021.1
수록면
562 - 568 (7page)

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Background/Aims: The intensities of injection pain resulting from the use of long- and mediumchain triglyceride (LCT/MCT) propofol and conventional LCT propofol during esophagogastroduodenoscopy (EGD) have yet to be compared. We aimed to determine the pain intensity caused by different formulations of propofol and to evaluate the formulation that would be preferred by patients as a sedative agent during their next procedure. Methods: This study was a single-center, randomized, controlled, and double-blind trial. Pain intensity was estimated 30 seconds after propofol injection by an examiner who was blinded to the group assignment using a numeric (0?10) pain rating scale (NPRS). After 1 week, the patients were asked whether they could recall the pain and were willing to receive the same agent for their next EGD. Results: One hundred twenty-nine patients were randomly assigned to LCT/MCT or LCT group. Although there was no significant difference in pain incidence between the LCT/MCT and LCT groups (52.9% vs 65.6%, p=0.156), the pain intensity was significantly lower in the LCT/MCT group (NPRS median [interquartile range]; 1 (0?2) vs 2 (0?5), p=0.005). After 1 week, fewer patients in the LCT/MCT group recalled the pain (19.1% vs 63.9%, p<0.001) and more patients in the LCT/MCT group were more willing to use the same agent for their next procedure (86.8% vs 72.1%, p=0.048) than in the LCT group. Conclusions: LCT/MCT propofol significantly reduced injection pain intensity compared to LCT propofol during EGD and preferred by patients as a sedative agent during their next EGD.
#Endoscopy #Medium chain triglyceride #Propofol #Pain

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참고문헌 (31)

참고문헌 신청
Cohen LB / 2010 / Sedation in digestive endoscopy : the Athens international position statements / Aliment Pharmacol Ther 32:425~442 google schola Nishizawa T / 2018 / Propofol for gastrointestinal endoscopy / United European Gastroenterol J 6:801~805 google schola 이창균 / 2016 / Room for Quality Improvement in Endoscopist-Directed Sedation: Results from the First Nationwide Survey in Korea / Gut and Liver 10(1):83~94 dbpia Dumonceau JM / 2015 / Non-anesthesiologist administration of propofol for gastrointestinal endoscopy : European Society of Gastrointestinal Endoscopy, European Society of Gastroenterology and Endoscopy Nurses and Associates Guideline : updated June 2015 / Endoscopy 47:1175~1189 google schola Shafer A / 1988 / Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia / Anesthesiology 69:348~356 google schola

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