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논문 기본 정보

자료유형
학술저널
저자정보
Lee Han Ah (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Jung Joon Young (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Lee Young Sun (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Jung Young Kul (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Kim Ji Hoon (Department of Internal Medicine Korea University College of Medicine Seoul Korea) An Hyonggin (Department of Biostatistics Korea University College of Medicine Seoul Korea) Yim Hyung Joon (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Jeen Yoon Tae (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Yeon Jong Eun (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Byun Kwan Soo (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Um Soon Ho (Department of Internal Medicine Korea University College of Medicine Seoul Korea) Seo Yeon Seok (Department of Internal Medicine Korea University College of Medicine Seoul Korea)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제4호
발행연도
2021.1
수록면
599 - 605 (7page)

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Background/Aims: Most prognostic prediction models for patients with liver cirrhosis include serum total bilirubin (TB) level as a component. This study investigated prognostic performance of serum direct bilirubin (DB) and developed new DB level-based prediction models for cirrhosis. Methods: A total of 983 hospitalized patients with liver cirrhosis were included. DB-Model for End-Stage Liver Disease (MELD) score was calculated using MELD score formula, with serum DB level replacing TB level. Results: Mean age of study population was 56.1 years. Alcoholic liver disease was the most frequent underlying condition (471 patients, 47.9%). Within 6 months, 144 patients (14.6%) died or received liver transplantation due to severe liver dysfunction. The area under the receiver operating characteristic curve (AUROC) for prediction of 6-month mortality with DB level was significantly higher than that with TB level (p<0.001). The AUROC of DB-MELD score for prediction of 6-month mortality was significantly higher than that of MELD score (p<0.001). Patients were randomly divided into training (n=492) and validation (n=491) cohorts. A new prognostic prediction model, “Direct Bilirubin, INR, and Creatinine” (DiBIC) score, was developed based on the most significant predictors of 6-month mortality. In training set, AUROC of DiBIC score for prediction of 6-month mortality was 0.892, which was significantly higher than that of the MELD score (0.875, p=0.017), but not different from that of DB-MELD score (0.886, p=0.272). Similar results were observed in validation set. Conclusions: New prognostic models, DB-MELD and DiBIC scores, have good prognostic performance in liver cirrhosis patients, outperforming other currently available models.
#Direct bilirubin #Prognosis #Prediction model #Liver cirrhosis

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참고문헌 (28)

참고문헌 신청
Scaglione S / 2015 / The epidemiology of cirrhosis in the United States : a population-based study / J Clin Gastroenterol 49:690~696 google schola Kim HJ / 2013 / Important predictor of mortality in patients with end-stage liver disease / Clin Mol Hepatol 19:105~115 google schola Lee HA / 2018 / Risk factors for dropout from the liver transplant waiting list of hepatocellular carcinoma patients under locoregional treatment / Transplant Proc 50:3521~3526 google schola The Korean Association for the Study of the Liver / 2018 / 2017 KASL clinical practice guidelines management of hepatitis C: Treatment of chronic hepatitis C / Clinical and Molecular Hepatology 24(3):230~277 dbpia Dae Hoe Gu / 2018 / Clinical usefulness of psoas muscle thickness for the diagnosis of sarcopenia in patients with liver cirrhosis / Clinical and Molecular Hepatology 24(3):319~330 google schola

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