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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background : Acute pancreatitis is an important and serious disease even with a relatively low incidence. Also, previous studies suggest that the coexistence of Type 2 diabetes and acute pancreatitis is closely related to an increased risk of death. However, the risk of acute pancreatitis in patients treated with liraglutide, a GLP-1 receptor agonist, has not been adequately evaluated. Objective : This meta-analysis was conducted to investigate the association between the liraglutide and acute pancreatitis in patients with Type 2 diabetes. Methods : Forty-one studies were assessed, and the results of the included studies were quantitatively integrated using the meta-analysis. The incidence of the liraglutide-related acute pancreatitis was estimated. As a sub-group analysis, four studies were assessed for comparing the liraglutide-treated groups and the control groups (placebo or other antidiabetic drugs except GLP-1 receptor agonists). Results : The incidence of acute pancreatitis was 0.4% (95% confidence interval (CI) 0.3%-0.5%). The risk of acute pancreatitis was not significantly different between the liraglutide-treated groups and the control groups (odds ratio=1.412; 95% CI 0.290-6.866). Conclusion : The incidence of liraglutide-related acute pancreatitis was relatively low and not additionally increased compared to the other antidiabetic drugs. We suggest that this meta-analysis is meaningful as evidence for the clinical use of liraglutide.
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참고문헌 (60)
참고문헌 신청
The top 10 causes of death / Who.int
김보연 / 2019 / Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current Status / Diabetes and Metabolism Journal 43(4):487~494
Nuffer WA / 2015 / Liraglutide : A new option for the treatment of obesity / Pharmacotherapy 35(10):926~934
Bode B / 2012 / An overview of the pharmacokinetics, efficacy and safety of liraglutide / Diabetes Res Clin Pract 97(1):27~42
Dungan KM / 2014 / Once-weekly dulaglutide versus oncedaily liraglutide in metformin-treated patients with type 2 diabetes(AWARD-6) : A randomised, open-label, phase 3, non-inferiority trial / Lancet 384(9951):1349~1357
김보연 / 2019 / Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current Status / Diabetes and Metabolism Journal 43(4):487~494
Nuffer WA / 2015 / Liraglutide : A new option for the treatment of obesity / Pharmacotherapy 35(10):926~934
Bode B / 2012 / An overview of the pharmacokinetics, efficacy and safety of liraglutide / Diabetes Res Clin Pract 97(1):27~42
Dungan KM / 2014 / Once-weekly dulaglutide versus oncedaily liraglutide in metformin-treated patients with type 2 diabetes(AWARD-6) : A randomised, open-label, phase 3, non-inferiority trial / Lancet 384(9951):1349~1357
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