지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 18 - 27 (10page)
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Background and Objectives: Fine needle aspiration cytology (FNAC) combined with washout thyroglobulin (Tg)measurement is the gold standard for the evaluation of metastatic lymph nodes (LNs) in thyroid cancer. However,few studies have assessed the clinical outcomes of discordant results between FNAC and washout Tg based onsurgery status and follow-up imaging in real-world practice. Materials and Methods: A total of 707 LNs in 512patients who underwent FNAC and washout Tg measurements from 2015 to 2017 were analyzed. The final LNoutcomes were confirmed through postoperative histology, or through metastatic FNAC findings combined withhigh washout Tg level, follow-up imaging studies, or repeat FNA, if LNs were not dissected. Results: The cut-offvalues of washout Tg for indicating LN metastasis in preoperative and postoperative LNs were 9.6 ng/mL and2.1 ng/mL. The diagnostic accuracy was improved by applying washout Tg according to surgery status and theresults of discordant rate was reduced, Discordant between results of FNAC with washout Tg and final outcomewere 9.2% (27/295) of preoperative LNs and 8.7% (36/412) of postoperative LNs. Due to inconclusive results,unnecessary neck dissection can occur in 13.9% (36/259 dissected cases). Conclusion: To improve diagnosticaccuracy, cut-off values of washout Tg should be applied depending on surgery status. New biomarkers in washoutfluid is necessary to resolve discordant findings.
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참고문헌 (29)
참고문헌 신청
DeSantis CE / 2019 / Cancer statistics for African Americans, 2019 / CA Cancer J Clin 69(3):211~233
Sakorafas GH / 2010 / Cervical lymph node dissection in papillary thyroid cancer : current trends, persisting controversies, and unclarified uncertainties / Surg Oncol 19(2):e57~e70
Sherman SI / 2013 / Thyroid cancer / Springer :295~310
Wang LY / 2014 / Central lymph node characteristics predictive of outcome in patients with differentiated thyroid cancer / Thyroid 24(12):1790~1795
Conzo G / 2013 / Total thyroidectomy, without prophylactic central lymph node dissection, in the treatment of differentiated thyroid cancer. Clinical retrospective study on 221 cases / Endocrine 44(2):419~425
Sakorafas GH / 2010 / Cervical lymph node dissection in papillary thyroid cancer : current trends, persisting controversies, and unclarified uncertainties / Surg Oncol 19(2):e57~e70
Sherman SI / 2013 / Thyroid cancer / Springer :295~310
Wang LY / 2014 / Central lymph node characteristics predictive of outcome in patients with differentiated thyroid cancer / Thyroid 24(12):1790~1795
Conzo G / 2013 / Total thyroidectomy, without prophylactic central lymph node dissection, in the treatment of differentiated thyroid cancer. Clinical retrospective study on 221 cases / Endocrine 44(2):419~425
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