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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Acne is one of the most common dermatological conditions, but the detailed pathology is unclear and current treatment regimens are plagued by side effects. Cutibacterium acnes is known as a major acne associated bacterium that derives energy from lipase mediated sebum lipid degradation. C. acnes is commensal, but free fatty acids digested by C. acnes lipases from triglyceride and lysophosphatidyl choline induce marked inflammation. Up to date, it remains to be elucidated the lipase activity mechanism at the molecular level. In this study, we report the purification and crystallization of the fulllength lysophospholipase from C. acnes. The crystal diffracted X-rays to a 1.7 A resolution, revealing that the crystals belong to space group P21212, with cell dimension parameters of a = 94.5, b = 129.7, and c = 55.5 A. Two protomers are present in the crystallographic asymmetric unit, with a calculated crystal volume per protein weight (VM) of 2.50 A3Da-1 and a solvent content of 50.79%. This structure will contribute towards revealing a detailed mechanism of acne development.
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참고문헌 (13)
참고문헌 신청
Cabrita, L. D. / 2006 / A family of E. coli expression vectors for laboratory scale and high throughput soluble protein production / BMC Biotechnol 6:12
Cogen, A. L. / 2008 / Skin microbiota: a source of disease or defence? / Br J Dermatol 158:442~455
Dréno, B. / 2018 / Cutibacterium acnes(Propionibacterium acnes)and acne vulgaris : a brief look at the latest updates / J Eur Acad Dermatol Venereol 32(Suppl 2):5~14
Eschenfeldt, W. H. / 2009 / A family of LIC vectors for high-throughput cloning and purification of proteins / Methods Mol Biol 498:105~115
Gupta, M. A. / 1998 / Depression and suicidal ideation in dermatology patients with acne, alopecia areata, atopic dermatitis and psoriasis / Br J Dermatol 139:846~850
Cogen, A. L. / 2008 / Skin microbiota: a source of disease or defence? / Br J Dermatol 158:442~455
Dréno, B. / 2018 / Cutibacterium acnes(Propionibacterium acnes)and acne vulgaris : a brief look at the latest updates / J Eur Acad Dermatol Venereol 32(Suppl 2):5~14
Eschenfeldt, W. H. / 2009 / A family of LIC vectors for high-throughput cloning and purification of proteins / Methods Mol Biol 498:105~115
Gupta, M. A. / 1998 / Depression and suicidal ideation in dermatology patients with acne, alopecia areata, atopic dermatitis and psoriasis / Br J Dermatol 139:846~850
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