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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 486 - 486 (1page)
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Lipid-bilayer nanodiscs encircled by membrane scaffold proteins (MSPs) have been used to study membrane proteins of interest in a physiological environment. Here, we suggest novel nanodisc-based approach to deal with influenza virus infection. Mechanistically, nanodiscs carrying gangliosides bind to influenza virions and are coendocytosed into host cells. At low pH in the endosome, the nanodiscs rupture the viral envelope, trapping viral RNAs inside the endolysosome for enzymatic decomposition. To improve stability and antiviral effect, we further established large nanodisc with ganglioside receptors whose belt proteins were circularized. Through enlarged area of large nanodisc, they ... 전체 초록 보기
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