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논문 기본 정보

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학술저널
저자정보
Soukaina Zouine (Laboratory of Biotechnology and Experimental Medicine Faculty of Medicine and Pharmacy University) Farida Marnissi (University Hospital Ibn Rochd) Nada Otmani (University of Hassan II Casablanca) Mohamed Bennani Othmani (Laboratory of Medical Informatics Faculty of Medicine and Pharmacy University of Hassan II Casabla) Nabil Zaid (Department of Biology Faculty of Sciences Mohammed V University Rabat Morocco) Kevin Kojok (Laboratory of Thrombosis and Hemostasis Montreal Heart Institute Montreal QC Canada) Younes Zaid (Department of Medicine Research Center Abulcasis University of Health Sciences Rabat Madinat Al I) Nadia Tahiri Jouti (University of Hassan II Casablanca) Norddine Habti (Laboratory of Biotechnology and Experimental Medicine Faculty of Medicine and Pharmacy University)
저널정보
한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.23 No.1
발행연도
2020.1
수록면
69 - 79 (11page)

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Purpose: Aberrant glycosylation of the histo-blood group antigens (including the angina bullosa haemorrhagica [ABH]) is often observed during malignant transformation in most types of carcinomas. Data concerning their ethnic distributions are diverse which explains why their biological characteristics have to be studied in different populations. Our aim was to analyze the expression of the histo-blood group (specifically the ABH) antigens in breast carcinoma. Methods: The expression of the histo-blood group (specifically the ABH) antigens was studied in 109 patients with breast carcinoma using immunohistochemistry. Statistical analysis was performed using χ2 and Fisher analyses. Results: The loss of expression of histo-blood group (ABH) antigens in breast carcinoma was observed in 81.13% of patients with blood group O, 37.93% with blood group A, and 96.30% with blood group B. One key finding of this study was that the loss of expression of the ABH antigen was also observed in normal tissues adjacent to the tumor. The loss of expression was associated with higher tumor grade (p < 0.05). Expression of H antigen was observed in 50% of cases with loss of expression of B antigen and was associated with human epidermal growth factor receptor 2 (HER2) overexpression (p < 0.05). The loss of H antigen in patients with blood group O was associated with estrogen receptor expression (p < 0.001). Incompatible A antigen in tumor was expressed in 20.75% of patients with blood group O. Conclusion: Loss of the ABH antigens correlated with the Scarff-Bloom-Richardson histologic grading. H antigen was associated with HER2 overexpression in breast cancer. However, further studies are needed to determine the role of incompatible A antigen in mammary carcinogenesis.
#Antigens #Blood #Breast #Carcinoma #Histocompatibility

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참고문헌 (30)

참고문헌 신청
Storry JR / 2009 / The ABO blood group system revisited : a review and update / Immunohematology 25:48~59 google schola Wang B / 1994 / Measuring H type 1 and H type 2 antigens in human saliva by immunoassay using artificial antigens as standard substances / Forensic Sci Int 67:1~8 google schola Orntoft TF / 1991 / Differential tissue expression of the Lewis blood group antigens: enzymatic, immunohistologic, and immunochemical evidence for Lewis a and b antigen expression in Le(a-b-) individuals / Blood 77:1389~1396 google schola Alfaro JA / 2008 / ABO(H)blood group A and B glycosyltransferases recognize substrate via specific conformational changes / J Biol Chem 283:10097~10108 google schola Ravn V / 2000 / Tissue distribution of histo-blood group antigens / APMIS 108:1~28 google schola

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