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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Ryo Imakiire (National Hospital Organization Mie National Hospital) 다카오후지사와 (National Hospital Organization Mie National Hospital) Mizuho Nagao (National Hospital Organization Mie National Hospital) Reiko Tokuda (National Hospital Organization Mie National Hospital) Tomoki Hattori (National Hospital Organization Mie National Hospital) Keigo Kainuma (National Hospital Organization Mie National Hospital) Yoshifumi Kawano (Kagoshima University Graduate School of Medicine)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.12 No.4
발행연도
2020.1
수록면
641 - 652 (12page)

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Purpose: The basophil activation test (BAT) has been reported to be useful for the diagnosis of various food allergies, such as allergy to peanut, but not to fish. This study aimed to evaluate the diagnostic performance of the BAT for fish allergy. Methods: We performed a retrospective review of patients with fish allergy who underwent the BAT using a panel of fish extracts (15 kinds) to examine the differential reactivity to several species of fish. The BAT score for each extract was expressed as the ratio of CD203chigh% with the extract to that with anti-IgE antibody. Clinical reactivity to each fish was confirmed by positive oral food challenge or a typical history of fish-induced immediate allergy symptoms. Receiver-operating-characteristic (ROC) analysis was performed to evaluate the diagnostic performance. Results: Fifty-one patients with fish allergy were analyzed. Using extracts of 15 species of fish, the BAT was performed a total of 184 times on the patients. Clinical allergy to each species of fish was confirmed in 90 (48.9%) of those tests. ROC analysis yielded high areas under the curve for the BAT scores for the 5 most common fish species (0.72–0.88). The diagnostic accuracy ranged from 0.74 to 0.86. Using a tentative cutoff value of 0.3 deduced from the ROC analyses of the 5 fish species, the accuracy for other fish allergic reactions was generally high (0.6–1.0), except the fish tested in a small number of patients. Conclusions: The BAT score based on CD203c expression may be useful for fish allergy diagnosis, especially since a large variety of fish can be tested by the BAT using fish extracts prepared by a simple method.
#Basophil activation test #CD203c #fish allergy #allergen extract

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참고문헌 (43)

참고문헌 신청
Clausen M / 2018 / Fish oil in infancy protects against food allergy in Iceland-results from a birth cohort study / Allergy 73:1305~1312 google schola Papamichael MM / 2018 / The role of fish intake on asthma in children: a meta-analysis of observational studies / Pediatr Allergy Immunol 29:350~360 google schola Vasileiadou S / 2018 / Eating fish and farm life reduce allergic rhinitis at the age of twelve / Pediatr Allergy Immunol 29:283~289 google schola Hemmings O / 2018 / Basophil activation test: old and new applications in allergy / Curr Allergy Asthma Rep 18:77 google schola Moonesinghe H / 2016 / Prevalence of fish and shellfish allergy: a systematic review / Ann Allergy Asthma Immunol 117:264~272.e4 google schola

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