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학술저널
저자정보
Li Yan (Department of Otorhinolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical Un) Wang Wei (Department of Immunology School of Basic Medical Sciences Capital Medical University Beijing China.) Ying Sun (Department of Immunology School of Basic Medical Sciences Capital Medical University Beijing China.) Lan Feng (Department of Otorhinolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical Un) Zhang Luo (Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical Univers)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.3
발행연도
2021.1
수록면
363 - 374 (12page)

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Chronic rhinosinusitis with nasal polyps (CRSwNP), a type 2-based upper airway disease, is mainly characterized by high asthma comorbidity and recurrence after surgery. It has been shown that type 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13 released from T helper 2 (Th2) cells as well as group 2 innate lymphoid cells (ILC2s), contribute to chronic inflammation of CRSwNP. This review summarizes recent progresses made in our understanding of ILC2 activity, particularly ILC2 accumulation at airway inflammation sites, cooperation with Th2 cells in aggravating the CRSwNP inflammatory process and interactions with regulatory T cells (Tregs) in resisting Tregs-mediated suppressive function in allergic inflammation. A better understanding of the biology of ILC2s should lay a good foundation in elucidating the pathogenesis of CRSwNP, and subsequently may lead to the development of new therapeutic strategies for the management of CRSwNP.

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