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논문 기본 정보

자료유형
학술저널
저자정보
Eunyoung Emily Lee (Division of Rheumatology Department of Internal Medicine Seoul National University Hospital Seoul K) Min Jung Kim (Division of Rheumatology Department of Internal Medicine Seoul National University Hospital Seoul K) Yeong Wook Song (Division of Rheumatology Department of Internal Medicine Seoul National University Hospital Seoul K) Jin Kyun Park (Division of Rheumatology Department of Internal Medicine Seoul National University Hospital Seoul K)
저널정보
대한류마티스학회 대한류마티스학회지 대한류마티스학회지 제27권 제2호
발행연도
2020.1
수록면
116 - 119 (4page)

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The treatment of adult-onset Still’s disease (AOSD) aims to control systemic inflammation and prevent organ damage. Systemic inflammation can be controlled with corticosteroid (CS) monotherapy in most cases. However, symptoms often flare as CS is tapered, often requiring long-term CS treatment, with its associated risks of infection, cardiovascular disease, and osteoporosis. Disease-modifying antirheumatic drugs (DMARDs) are often used as CS-sparing agents; however, the choice of DMARD has been largely empirical. Methotrexate (MTX) is recommended as the first-line steroid-sparing drug due to its well-known efficacy and safety in rheumatoid arthritis (RA). When MTX treatment is unsuccessful in AOSD, the choice of a second-line drug has not been established. In RA, leflunomide (LEF) has been used as an alternative to or in combination with MTX. To date, there has been no adequate assessment of the combination of LEF and MTX in AOSD. Here, we report a case of refractory chronic AOSD successfully treated with the MTX-LEF combination.

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