지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 150 - 158 (9page)
이용수
초록· 키워드
오류제보하기
Objective. To elucidate whether clinical features and the weighted genetic risk score (wGRS) were associated with the presence of lupus nephritis (LN). Methods. We retrospectively divided patients with systemic lupus erythematosus (SLE, n=1,078) into biopsy-proven LN (n=507) and non-LN groups (non-LN, n=571). Baseline clinical features, serologic markers, and the wGRS were collected. The wGRS was calculated from 112 non-human leukocyte antigen (non-HLA) loci and HLA-DRβ1 amino acid haplotypes for SLE. Associations among clinical features, wGRS, and the presence of LN were identified. Results. In the multivariate analysis, patients with LN were younger at diagnosis (odds ratio [OR]=0.97, p＜0.001), had more pleuritis (OR=2.44, p＜0.001) and pericarditis (OR=1.62, p=0.029), had a higher detection rate of anti-double stranded deoxyribonucleic acid (anti-dsDNA antibodies, OR=2.22, p＜0.001), anti-Smith antibodies (anti-Sm antibodies, OR=1.70, p=0.002), low level of complement (OR=1.37, p=0.043) and absence of antiphospholipid antibodies (aPL antibodies, OR=1.60, p=0.002), and had higher wGRS (OR=1.16, p=0.012). Mediation analysis suggested that anti-Sm antibodies and low complement could be mediators in the relationship between high wGRS and the presence of LN. Conclusion. Onset age, pleuritis, pericarditis, several serologic markers, and wGRS were associated with the presence of LN. Anti-Sm antibodies and low complement appeared to mediate the indirect relationship between wGRS and the presence of LN
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Tsokos GC / 2011 / Systemic lupus erythematosus / N Engl J Med 365:2110~2121
Formiga F / 1999 / Mild presentation of systemic lupus erythematosus in elderly patients assessed by SLEDAI. SLE Disease Activity Index / Lupus 8:462~465
Hanly JG / 2016 / The frequency and outcome of lupus nephritis:results from an international inception cohort study / Rheumatology(Oxford) 55:252~262
Fiehn C / 2003 / Improved clinical outcome of lupus nephritis during the past decade : importance of early diagnosis and treatment / Ann Rheum Dis 62:435~439
Ntatsaki E / 2015 / Risk factors for renal disease in systemic lupus erythematosus and their clinical implications / Expert Rev Clin Immunol 11:837~848
Formiga F / 1999 / Mild presentation of systemic lupus erythematosus in elderly patients assessed by SLEDAI. SLE Disease Activity Index / Lupus 8:462~465
Hanly JG / 2016 / The frequency and outcome of lupus nephritis:results from an international inception cohort study / Rheumatology(Oxford) 55:252~262
Fiehn C / 2003 / Improved clinical outcome of lupus nephritis during the past decade : importance of early diagnosis and treatment / Ann Rheum Dis 62:435~439
Ntatsaki E / 2015 / Risk factors for renal disease in systemic lupus erythematosus and their clinical implications / Expert Rev Clin Immunol 11:837~848
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Predictive Factors for Renal Response in Lupus Nephritis: A Single-center Prospective Cohort Study
대한류마티스학회지
2022 .10
-
Worse Renal Presentation and Prognosis in Initial-Onset Lupus Nephritis than Early-Onset Lupus Nephritis
Yonsei Medical Journal
2020 .01
-
Evaluating the association of interleukin-10 gene promoter -592 A/C polymorphism with lupus nephritis susceptibility
Kidney Research and Clinical Practice
2016 .01
-
Chronologic trends of cancer-related lymph node research in PubMed: informetrics analysis
Annals of Surgical Treatment and Research
2020 .11
-
The impact of lymph node count on survival in gastric cancer
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2018 .12
-
Clinical significance of lymph node size in locally advanced cervical cancer treated with concurrent chemoradiotherapy
Journal of Yeungnam Medical Science
2019 .01
-
Self-Reported Physical Activity Is Associated with Lupus Nephritis in Systemic Lupus Erythematosus: Data from KORean Lupus Network (KORNET) Registry
Yonsei Medical Journal
2018 .01
-
Is the Initial Size of Tuberculous Lymphadenopathy associated with Lymph Node Enlargement during Treatment?
Infection and Chemotherapy
2017 .06
-
Distribution of Lymph Nodes in Stage III Patients With Mid and Low Rectal Cancer: Preliminary Study
Annals of Coloproctology
2018 .01
-
Clinical characteristics and prognostic value of autoantibody profile in children with monogenic lupus
대한류마티스학회지
2024 .07
-
The prognosis factors among breast cancer patients with extensive axillary lymph node metastasis
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2018 .06
-
Anti-Sm Antibody, Damage Index, and Corticosteroid Use are Associated with Cardiac Involvement in Systemic Lupus Erythematosus: Data from a Prospective Registry Study
Journal of Korean Medical Science
2020 .01
-
Acoustic radiation force impulse imaging of biopsy-proven Kikuchi disease: initial experiences for evaluating feasibility in pediatric patients
ULTRASONOGRAPHY
2019 .01
-
Breast Cancer – Management of LN Metastasis According to the Level
대한외과학회 학술대회 초록집
2021 .11
-
Delineating the Risk of Lupus Nephritis: How Far Have We Come?
대한류마티스학회지
2021 .10
-
Is Lymph Node Size a Reliable Factor for Estimating Lymph Node Metastasis in Early Gastric Cancer?
Journal of Gastric Cancer
2018 .03
-
A Case Report of Male Systemic Lupus Erythematous with Antinuclear Antibodies-Negative: A Challenging Diagnosis
Korean Journal of Family Medicine
2022 .03
-
Antiphospholipid Antibody Positivity and the Clinical Outcomes of Patients with Systemic Lupus Erythematosus
대한류마티스학회지
2018 .01
-
Urinary Tumor Necrosis Factor-like Weak Inducer of Apoptosis as a Biomarker for Lupus Nephritis: A Meta-analysis
대한류마티스학회지
2017 .01
-
A Case of Massive Pulmonary Embolism in Systemic Lupus Erythematosus without Antiphospholipid Antibody
대한류마티스학회지
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0