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논문 기본 정보

자료유형
학술저널
저자정보
김민경 (차의과학대학교) 박재균 (차의과학대학교 강남차병원 여성의학연구소) 전윤미 (차의과대학교) 최승아 (차의과학대학교) 이희준 (차의과학대학교) 김재연 (차의과학대학교) 장은미 (차의과학대학교) 김지원 (차의과학대학교) 유상우 (차의과학대학교) 김진영 (차의과학대학교) 곽인평 (차의과학대학교) 이우식 (차의과학대학교) 윤태기 (차의과학대학교)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.34 No.4
발행연도
2019.1
수록면
1 - 11 (11page)

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Background: The standard morphological evaluation has been widely used for embryo selection, but it has limitations. This study aimed to investigate the correlation between morphologic grading and euploidy rate of in vitro fertilization (IVF) preimplantation genetic screening (PGS) and compare the pregnancy rates in young and old ages. Methods: This is a retrospective study using the medical records of patients who underwent IVF procedures with PGS between January 2016 and February 2017 in a single center. The embryo grades were categorized into 4 groups: excellent, good, fair, and poor. Basic characteristics, euploidy rates, clinical pregnancy (CP) rates and ongoing pregnancy rates were analyzed. Results: The excellent group had significantly higher rate of euploid embryos than fair group (47.82% vs. 29.33%; P = 0.023) and poor group (47.82% vs. 29.60%; P = 0.005). When the four groups were recategorized into two groups (excellent and good vs. fair and poor), they also showed significant difference in euploidy rates (44.52% vs. 29.53%; P = 0.002). When the patients were divided into two groups by age 35, the CP rates for those under and over 35 years old were 44.74% and 47.83%, respectively, which showed no significant difference. Conclusion: The significant differences among the euploidy rates of different morphologic embryo grades demonstrated the positive correlations between the morphologic grading of the embryo and the euploidy rate of PGS. Additionally, there was no significant difference between the younger and older patients' CP rates. These findings emphasize the fact that old age patients might benefit from PGS whatever the indication of PGS is.

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