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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 12 (12page)
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초록· 키워드
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Background: Twin-to-twin transfusion syndrome (TTTS) is a serious complication of monochorionic twin pregnancies. It results from disproportionate blood supply to each fetus caused by abnormal vascular anastomosis within the placenta. Amniotic fluid (AF) is an indicator reflecting the various conditions of the fetus, and an imbalance in AF volume is essential for the antenatal diagnosis of TTTS by ultrasound. In this study, two different mass spectrometry quantitative approaches were performed to identify differentially expressed proteins (DEPs) within matched pairs of AF samples. Methods: We characterized the AF proteome in pooled AF samples collected from donor and recipient twin pairs (n = 5 each) with TTTS by a global proteomics profiling approach and then preformed the statistical analysis to determine the DEPs between the two groups. Next, we carried out a targeted proteomic approach (multiple reaction monitoring) with DEPs to achieve high-confident TTTS-associated AF proteins. Results: A total of 103 AF proteins that were significantly altered in their abundances between donor and recipient fetuses. The majority of upregulated proteins identified in the recipient twins (including carbonic anhydrase 1, fibrinogen alpha chain, aminopeptidase N, alpha-fetoprotein, fibrinogen gamma chain, and basement membrane-specific heparan sulfate proteoglycan core protein) have been associated with cardiac or dermatologic disease, which is often seen in recipient twins as a result of volume overload. In contrast, proteins significantly upregulated in AF collected from donor twins (including IgGFc-binding protein, apolipoprotein C-I, complement C1q subcomponent subunit B, apolipoprotein C-III, apolipoprotein A-II, decorin, alpha-2-macroglobulin, apolipoprotein A-I, and fibronectin) were those previously shown to be associated with inflammation, ischemic cardiovascular complications or renal disease. Conclusion: In this study, we identified proteomic biomarkers in AF collected from donor and recipient twins in pregnancies complicated by TTTS that appear to reflect underlying functional and pathophysiological challenges faced by each of the fetuses.
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참고문헌 (26)
참고문헌 신청
Lewi L / 2008 / The outcome of monochorionic diamniotic twin gestations in the era of invasive fetal therapy : a prospective cohort study / Am J Obstet Gynecol 199(5):514.e1~514.e8
Nikkels PG / 2008 / Pathology of twin placentas with special attention to monochorionic twin placentas / J Clin Pathol 61(12):1247~1253
Bajoria R / 1995 / Angioarchitecture of monochorionic placentas in relation to the twin-twin transfusion syndrome / Am J Obstet Gynecol 172(3):856~863
Quintero RA / 1999 / Staging of twin-twin transfusion syndrome / J Perinatol 19(8 Pt 1):550~555
Paek B / 2016 / Atypical twin-to-twin transfusion syndrome : prevalence in a population undergoing fetoscopic laser ablation of communicating placental vessels / Am J Obstet Gynecol 215(1):115.e1~115.e5
Nikkels PG / 2008 / Pathology of twin placentas with special attention to monochorionic twin placentas / J Clin Pathol 61(12):1247~1253
Bajoria R / 1995 / Angioarchitecture of monochorionic placentas in relation to the twin-twin transfusion syndrome / Am J Obstet Gynecol 172(3):856~863
Quintero RA / 1999 / Staging of twin-twin transfusion syndrome / J Perinatol 19(8 Pt 1):550~555
Paek B / 2016 / Atypical twin-to-twin transfusion syndrome : prevalence in a population undergoing fetoscopic laser ablation of communicating placental vessels / Am J Obstet Gynecol 215(1):115.e1~115.e5
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