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논문 기본 정보

자료유형
학술저널
저자정보
Jang Boo-ok (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit) Choi Gwang Hyeon (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit) Jang Hee Yoon (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit) Ahn Soomin (Department of Pathology Seoul National University Bundang Hospital Seoul National University Colleg) Choi Jae Kyun (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit) Kim Siho (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit) Lee Kyunghan (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit) Jang Eun Sun (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit) Kim Jin-Wook (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit) 정숙향 (서울대학교)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.35 No.28
발행연도
2020.1
수록면
1 - 6 (6page)

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N,N-dimethylformamide (DMF), a widely used solvent in the chemical industry, is known to induce toxic hepatitis. However, there have been no reported cases of DMF-associated autoimmune hepatitis. A 31-year-old healthy man working at a glove factory since July 2015 had intermittently put his bare hands into a diluted DMF solution for his first 15 days at work. After 2 months, he felt nausea, fatigue, and hand cramping, and a jaundice followed. His laboratory findings showed positive autoantibodies and elevated immunoglobulin G (IgG), and his liver biopsy pathology was typical of autoimmune hepatitis (AIH). Prednisolone and azathioprine therapy began, and he recovered rapidly without adverse events. Though his liver chemistry was normalized, the IgG level remained persistently upper normal range. His 2nd liver biopsy performed in April 2019 showed mild portal activity, and he was well under a low dose immunosuppressive therapy up to April 2020. This case warns of the hazard of occupational exposure to DMF, and clinicians should be aware of DMF-related AIH for timely initiation of immunosuppressive therapy.

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