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논문 기본 정보

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학술저널
저자정보
Yeo Hye Ju (Division of Pulmonary Allergy and Critical Care Medicine Department of Internal Medicine Pusan Nati) Kim Do Hyung (Department of Thoracic and Cardiovascular Surgery Pusan National University Yangsan Hospital Yangsa) Kim Yun Seong (Division of Pulmonary Allergy and Critical Care Medicine Department of Internal Medicine Pusan Nati) Jeon Doosoo (Division of Pulmonary Allergy and Critical Care Medicine Department of Internal Medicine Pusan Nati) Cho Woo Hyun (Division of Pulmonary Allergy and Critical Care Medicine Department of Internal Medicine Pusan Nati)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.12
발행연도
2021.1
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1 - 11 (11page)

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Background: There is currently a lack of data on the impact of the recent revision of the domestic lung allocation system on transplant performance. Methods: We conducted a retrospective analysis of transplant candidates and transplant patients registered in Korean Network for Organ Sharing between July 2015 and July 2019. Study periods were classified according to the introduction of the revised lung allocation system as follows: period 1 from July 2015 to June 2017 and period 2 from August 2017 to July 2019. Results: During the study period, a total of 627 patients were on the waiting list, of which 398 lung transplantations were performed. Total waiting list size increased by 98.6%, from 210 in period 1 to 417 in period 2. The number of transplant patients also increased by 32.7%, from 171 in period 1 to 227 in period 2. The number of donors decreased from 1,042 to 878, whereas the usage rate, i.e., the number of lung donors used for transplantation among the total number of reported lung donors, increased from 16.4% to 25.9%. The proportion of patients with high urgent status at transplantation increased from 45% to 60.4%, whereas those with urgent status decreased from 46.8% to 35.7% (P = 0.006). The use of marginal donor lungs increased from 29.8% to 53.7% (P < 0.001). To adjust urgency status and marginal donor usage between two groups, we conducted a propensity score matching analysis. No significant differences were detected in 1-year survival rates between the two periods after propensity score matching. As well, no significant difference was observed in mortality on the waiting list between the two periods. Conclusion: The recent revision of the lung allocation system in Korea did not change the performance of lung transplant in terms of waiting list mortality and 1-year survival. The rapid increase in the volume of waiting list between the two periods increased the waiting time, transplantation of high-urgency patients, and use of marginal lung donors.
#Lung Transplantation #Lung Allocation System #Korea #Mortality

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참고문헌 (15)

참고문헌 신청
Khush KK / 2018 / The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation : thirty-fifth adult heart transplantation report-2018; focus theme : multiorgan transplantation / J Heart Lung Transplant 37(10):1155~1168 google schola Korean Network for Organ Sharing / 2018 annual report for organ transplant and tissue donation google schola Yu WS / 2019 / The lung allocation score could evaluate allocation systems in countries that do not use the score / PLoS One 14(4):e0214853 google schola Korean Network for Organ Sharing / Organ transplantation law google schola Russo MJ / 2010 / High lung allocation score is associated with increased morbidity and mortality following transplantation / Chest 137(3):651~657 google schola

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