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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
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Background: It is uncertain whether non-alcoholic fatty liver disease (NAFLD) is associated with subclinical hypothyroidism (SH) in pediatric patients. The purpose of this study was to investigated the prevalence and related factors of SH in pediatric patients with NAFLD. We also evaluate the association between liver fibrosis and SH. Methods: We retrospectively reviewed medical records for patients aged 4 to 18 years who were diagnosed with NAFLD and tested for thyroid function from January 2015 to December 2019 at 10 hospitals in Korea. Results: The study included 428 patients with NAFLD. The prevalence of SH in pediatric NAFLD patients was 13.6%. In multivariate logistic regression, higher levels of steatosis on ultrasound and higher aspartate aminotransferase to platelet count ratio index (APRI) score were associated with increased risk of SH. Using receiver operating characteristic curves, the optimal cutoff value of the APRI score for predicting SH was 0.6012 (area under the curve, 0.67; P < 0.001; sensitivity 72.4%, specificity 61.9%, positive predictive value 23%, and negative predictive value 93.5%). Conclusion: SH was often observed in patients with NAFLD, more frequently in patients with more severe liver damage. Thyroid function tests should be performed on pediatric NAFLD patients, especially those with higher grades of liver steatosis and fibrosis.
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참고문헌 (40)
참고문헌 신청
Yu EL / 2019 / Prevalence of nonalcoholic fatty liver disease in children with obesity / J Pediatr 207:64~70
Chalasani N / 2018 / The diagnosis and management of nonalcoholic fatty liver disease : practice guidance from the American Association for the Study of Liver Diseases / Hepatology 67(1):328~357
Kaltenbach TE / 2017 / Thyroid dysfunction and hepatic steatosis in overweight children and adolescents / Pediatr Obes 12(1):67~74
Ferrandino G / 2017 / Pathogenesis of hypothyroidism-induced NAFLD is driven by intra-and extrahepatic mechanisms / Proc Natl Acad Sci U S A 114(43):E9172~E9180
Ma S / 2015 / Thyrotropin and obesity : increased adipose triglyceride content through glycerol-3-phosphate acyltransferase 3 / Sci Rep 5(1):7633
Chalasani N / 2018 / The diagnosis and management of nonalcoholic fatty liver disease : practice guidance from the American Association for the Study of Liver Diseases / Hepatology 67(1):328~357
Kaltenbach TE / 2017 / Thyroid dysfunction and hepatic steatosis in overweight children and adolescents / Pediatr Obes 12(1):67~74
Ferrandino G / 2017 / Pathogenesis of hypothyroidism-induced NAFLD is driven by intra-and extrahepatic mechanisms / Proc Natl Acad Sci U S A 114(43):E9172~E9180
Ma S / 2015 / Thyrotropin and obesity : increased adipose triglyceride content through glycerol-3-phosphate acyltransferase 3 / Sci Rep 5(1):7633
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