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논문 기본 정보

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저자정보
Yoon Jae Hyun (Department of Internal Medicine Chonnam National University Hospital School of Medicine Gwangju Kor) Jun Chung Hwan (Department of Internal Medicine Chonnam National University Hospital School of Medicine Gwangju Kor) Kim Jeong Han (Department of Internal Medicine Konkuk University School of Medicine Seoul Korea.) Yoon Eileen L. (Department of Internal Medicine Inje University Sanggye Paik Hospital Seoul Korea.) Kim Byung Seok (Department of Internal Medicine Daegu Catholic University School of Medicine Daegu Korea.) Song Jeong Eun (Department of Internal Medicine Daegu Catholic University School of Medicine Daegu Korea.) Suk Ki Tae (Department of Internal Medicine Hallym University College of Medicine Chuncheon Korea.) Kim Moon Young (Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Korea.) Kang Seong Hee (Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.21
발행연도
2021.1
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1 - 13 (13page)

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Background: Chronic hepatitis B is the most common cause of liver cirrhosis in South Korea. However, alcoholic liver disease has shown an increasing trend. Although the clinical implications surrounding liver cirrhosis have been changing over the years, few studies have recently examined cirrhosis epidemiology. Therefore, we aimed to investigate changes in liver cirrhosis etiology and severity in Korea. Methods: We retrospectively reviewed 16,888 records of cirrhotic patients from six tertiary hospitals in Korea from 2008 to 2017. Continuous and non-continuous variables were processed via linear and Poisson regression, expressed as beta (B) coefficients and as exponentiated values of coefficients (Exp[B]), respectively. Results: Chronic hepatitis B showed a decreasing trend (Exp[B] = 0.975, P < 0.001), whereas alcohol showed an increasing trend (Exp[B] = 1.013, P = 0.003), occupying the most common etiology in 2017. The Child-Turcotte-Pugh (CTP) score and decompensated liver cirrhosis prevalence did not change over the 10-year period. The incidence of variceal bleeding, severe ascites, hepatic encephalopathy, and spontaneous bacterial peritonitis significantly decreased from 12.3% to 7.7%, 7.8% to 4.1%, 1.0% to 0.5%, and 1.9% to 1.1%, respectively (P < 0.05 for all). In the subgroup analysis, the chronic hepatitis B group showed improving CTP scores (B = −0.025, P < 0.001) and decreasing decompensated liver cirrhosis rates (Exp[B] = 0.977, P = 0.016), whereas the alcohol group demonstrated increasing CTP class C (Exp[B] = 1.031, P = 0.005) and model for end-stage liver disease scores (B = 0.081, P = 0.005) over 10 years. Conclusion: The chronic hepatitis B group exhibited improved results, whereas the alcohol group still presented poor liver functions and outcomes. Future national policies and systematic approaches addressing the incidence, prevention, and treatment of alcoholic liver cirrhosis are indispensable.
#Alcohol #Cirrhosis #Epidemiology #Hepatitis B Virus

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참고문헌 (27)

참고문헌 신청
Cho EJ / 2017 / Current status and strategies for hepatitis B control in Korea / Clin Mol Hepatol 23(3):205~211 google schola Yoon JH / 2019 / Sofosbuvir plus ribavirin for the treatment of hepatitis C virus genotype 2 in Korea : what's the optimal dosage of ribavirin in real-world setting / J Dig Dis 20(1):31~37 google schola Youn Jae Lee / 2019 / An integrated analysis of elbasvir/grazoprevir in Korean patients with hepatitis C virus genotype 1b infection / Clinical and Molecular Hepatology 25(4):400~407 dbpia World Health Organization / Global Information System on Alcohol and Health (GISAH): levels of consumption. Global Health Observatory (GHO) data google schola Fan JG / 2017 / New trends on obesity and NAFLD in Asia / J Hepatol 67(4):862~873 google schola

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