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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 190 - 198 (9page)
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Chitosan (CTSN) and β-glycerophosphate (GP) based hydrogels were prepared and characterized to elucidate the chemical interactions involved in the formation of these hydrogels depending upon the molecular weight of chitosan. Characterization of nanostructure of the resulting hydrogels was investigated by Fourier Transform-Infrared Spectroscopy (FT-IR). We observed that the major interaction which might be responsible for the formation of these hydrogels is between phosphate groups (PO43-) of GP and amine groups of chitosan. Whereas, the addition of hyaluronic acid (HA) which may act as a crosslinker has a negative effect on available free phosphate groups in the hydrogel confirmed by FT-IR analysis (971.9 cm-1 peak). Decisively, the outcomes of spectrophotometric analysis also coincide with the findings of FT-IR for the CTSN/GP/HA thermo-hydrogel system. This study demonstrates the standard protocol to provide a practical approach for the analysis of interactions involved in the formation of CTSN/GP/HA hydrogels that could be potently useful in pharmacological and pharmaceutical applications.
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참고문헌 (28)
참고문헌 신청
Muzzarelli, R. / 1997 / Human enzymatic activities related to the therapeutic administration of chitin derivatives / CMLS, Cell. Mol. Life. Sci 53:131~140
Caon, T. / 2014 / Chitosan-decorated polystyrene-b-poly(acrylic acid)polymersomes as novel carriers for topical delivery of finasteride / Eur. J. Pharm. Sci 52:165~172
Wang, H. / 2014 / Docetaxel-loaded chitosan microspheres as a lung targeted drug delivery system: In vitroand in vivo evaluation / Int. J. Mol. Sci 15(3):3519~3532
Song, J. / 2001 / A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis / J. Nucl. Med 28:489~497
Qi, X. N. / 2014 / Preparation of chitosan/silk fibroin/hydroxyapatite porous scaffold and its characteristics in comparison to bi-component scaffolds / J. Biomed. Mater. Res. A 102(2):366~372
Caon, T. / 2014 / Chitosan-decorated polystyrene-b-poly(acrylic acid)polymersomes as novel carriers for topical delivery of finasteride / Eur. J. Pharm. Sci 52:165~172
Wang, H. / 2014 / Docetaxel-loaded chitosan microspheres as a lung targeted drug delivery system: In vitroand in vivo evaluation / Int. J. Mol. Sci 15(3):3519~3532
Song, J. / 2001 / A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis / J. Nucl. Med 28:489~497
Qi, X. N. / 2014 / Preparation of chitosan/silk fibroin/hydroxyapatite porous scaffold and its characteristics in comparison to bi-component scaffolds / J. Biomed. Mater. Res. A 102(2):366~372
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