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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1,165 - 1,171 (7page)
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Introduction The vertebral number is an economically significant trait, which is associated with body length and carcass traits. Nuclear Receptor Subfamily 6, Group A, Member 1 (NR6A1) is a member of the nuclear receptor superfamily and it plays an important role in the early development of embryos. Objectives The NR6A1 gene was considered as an important candidate for influence vertebrae number, while the potential associations between this gene and the number of lumbar vertebrae traits of sheep have not been explored. Methods In this study, we detected the genetic variants of NR6A1 gene and analyzed the associations of the polymorphisms with lumbar number traits in 130 Kazakh sheep. We use single-strand conformation polymorphism (SSCP) technique to detect single nucleotide polymorphism (SNP) of NR6A1 gene, and the association of the genotype and lumbar number variation was analyzed by independent Chi-square test. Results We detect SNP of NR6A1 gene by PCR-SSCP technique, and polymorphisms were only found in the coding region of exon-6 and exon-8 of NR6A1 gene. In order to investigate the connection between the SNP locus and lumbar number traits in sheep, we conducted a Chi-square test for independence for exon-6 and exon-8 of NR6A1 gene, respectively. Association analysis revealed significant associations between the SNP (rs414302710: A >C) in the exon-8 of NR6A1 gene with the number of lumbar vertebrae (P < 0.01). Conclusion Our study indicated that this SNP (rs414302710: A>C) locus of exon-8 of NR6A1 gene in sheep possible influence the number of lumbar vertebrae, which has the potential to be applied in selective breeding of sheep.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Agoulnik IY / 1998 / Cloning, expression analysis and chromosomal localization of the human nuclear receptor gene GCNF / FEBS Lett 424:73~78
Borchers N / 2004 / The number of ribs and vertebrae in a Pietrain cross : variation, heritability and effects on performance traits / J Anim Breed Genet 121:392~403
Braat AK / 1999 / Cloning and expression of the zebrafish germ cell nuclear factor / Mol Reproduct Dev Inc Gamete Res 53:369~375
Byun SO / 2009 / An effective method for silver-staining DNA in large numbers of polyacrylamide gels / Anal Biochem 385:174~175
Chen F / 1994 / Cloning of a novel orphan receptor(GCNF)expressed during germ cell development / Mol Endocrinol 8:1434~1444
Borchers N / 2004 / The number of ribs and vertebrae in a Pietrain cross : variation, heritability and effects on performance traits / J Anim Breed Genet 121:392~403
Braat AK / 1999 / Cloning and expression of the zebrafish germ cell nuclear factor / Mol Reproduct Dev Inc Gamete Res 53:369~375
Byun SO / 2009 / An effective method for silver-staining DNA in large numbers of polyacrylamide gels / Anal Biochem 385:174~175
Chen F / 1994 / Cloning of a novel orphan receptor(GCNF)expressed during germ cell development / Mol Endocrinol 8:1434~1444
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