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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,145 - 1,150 (6page)
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Background Human endogenous retroviruses (HERVs) constitute around 8% of the human genome and have important roles in human health and disease, including cancers. Previous studies showed that HERV envelope (Env) proteins are highly expressed in cancer tissues and co-related with cancer progression. KAP1 has been reported to play a key role in regulating retrotransposons, including HERV-K, through epigenetic silencing. Objective The relationship between KAP-1 and HERV Envs expressions was analyzed only in tumor cell lines and has not yet been studied in cancer tissues. In this study, we analyzed the expression patterns and relationship between KAP1 and HERV Env proteins in ovarian cancer tissues. Method The expression patterns of KAP-1 and HERV Env proteins, including HERV-K and HERV-R, were analyzed in ovarian cancer tissue microarrays that contained 80 surgical specimens, including normal ovary and malignant ovarian cancers. Results The expression of HERV-R Env and KAP1 proteins is signifcantly higher in ovarian cancer compared with normal ovary tissues. However, the expression of HERV-K Env did not change signifcantly in cancer tissues. The expression patterns of HERV-K Env and HERV-R Env signifcantly increased in early stages of cancer and KAP1 expression was higher in certain stage and types of cancers. However, the expression of HERV-K Env, HERV-R Env, and KAP1 did not change in diferent age groups. The correlation between the expression of KAP1 and HERV-Env, including HERV-K and HERV-R, was not signifcantly correlated. Conclusions The results of this study showed that there was no signifcant correlation between the expression of KAP1 and HERV Env proteins in ovarian cancer tissues, unlike studies with cell lines in vitro. These results suggest that the actual expression of HERV Env proteins in ovarian cancer tissues may be regulated through various complex factors as well as KAP1.
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참고문헌 (29)
참고문헌 신청
Belshaw R / 2004 / Long-term reinfection of the human genome by endogenous retroviruses / Proc Natl Acad Sci USA 101:4894~4899
Belshaw R / 2005 / Genomewide screening reveals high levels of insertional polymorphism in the human endogenous retrovirus family HERV-K(HML2) : implications for present-day activity / J Virol 79:12507~12514
Cheng CT / 2014 / KAPtain in charge of multiple missions : emerging roles of KAP1 / World J Biol Chem 5:308~320
Conley AB / 2008 / Retroviral promoters in the human genome / Bioinformatics 24:1563~1567
Contreras-Galindo R / 2008 / Human endogenous retrovirus K(HML-2)elements in the plasma of people with lymphoma and breast cancer / J Virol 82:9329~9336
Belshaw R / 2005 / Genomewide screening reveals high levels of insertional polymorphism in the human endogenous retrovirus family HERV-K(HML2) : implications for present-day activity / J Virol 79:12507~12514
Cheng CT / 2014 / KAPtain in charge of multiple missions : emerging roles of KAP1 / World J Biol Chem 5:308~320
Conley AB / 2008 / Retroviral promoters in the human genome / Bioinformatics 24:1563~1567
Contreras-Galindo R / 2008 / Human endogenous retrovirus K(HML-2)elements in the plasma of people with lymphoma and breast cancer / J Virol 82:9329~9336
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