지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 303 - 312 (10page)
이용수
이 논문의 연구 히스토리 (2)
2021
Inhibitory effects of Myelophycus caespitosus methanol extract on oxidative stress-induced cytotoxicity in C2C12 myoblasts through induction of heme oxygenase-1 expression
Yung Hyun Choi
,
Hyesook Lee
,
Cheol Pa
외 5명
한국수산과학회 양식분과 학술대회
2021.04
학술대회자료
Trans-cinnamaldehyde protects C2C12 myoblasts from DNA damage, mitochondrial dysfunction and apoptosis caused by oxidative stress through inhibiting ROS production
Yung Hyun Choi
Genes & Genomics
2021.01
학술저널
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Background Oxidative stress-induced myoblast damage is one of the major causes of skeletal muscle loss associated with inhibition of myogenic differentiation and muscle dysfunction. Trans-cinnamaldehyde (tCA), the most common essential oil constituent in cinnamon, is known to possess strong anti-oxidant activity. However, it has not been determined whether tCA can protect myoblasts from oxidative damage. Objectives The aim of this study was to investigate the protective effect of tCA against oxidative stress-induced damage in mouse myoblast C2C12 cells. Methods To examine the efficacy of tCA to protect against oxidative damage, cell viability, morphological changes, DNA damage, mitochondrial membrane potential (MMP) analysis, reactive oxygen species (ROS) generation, and Western blotting were applied. Results tCA suppressed hydrogen peroxide (H2O2)-induced growth inhibition and DNA damage by blocking abnormal ROS accumulation. In addition, tCA attenuated apoptosis by suppressing loss of MMP and cytosolic release of cytochrome c, increasing the rate of Bcl-2/Bax expression and reducing the activity of caspase-3 in H2O2-stimulated cells, suggesting that tCA protected C2C12 cells from mitochondria-mediated apoptosis caused by oxidative stress. Conclusion The results showed that tCA may be useful as a potential treatment for the prevention and treatment of various oxidative stress-related muscle disorders in the future.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Neuroprotective effects of urolithin A on H₂O₂-induced oxidative stress-mediated apoptosis in SK-N-MC cells
Nutrition Research and Practice
2020 .02
-
Neuroprotective effects of urolithin A on H₂O₂-induced oxidative stress-mediated apoptosis in SK-N-MC cells
Nutrition Research and Practice
2020 .02
-
Determination of the metabolic alterations of short-chain fatty acids and TCA cycle intermediates in human plasma with gastric disorders using GC-MS/MS
한국분석과학회 학술대회
2021 .11
-
Regulation of P. aeruginosa Elastase by TCA Cycle Enzymes
한국미생물학회 학술대회논문집
2019 .04
-
Fisetin Protects C2C12 Mouse Myoblasts from Oxidative Stress-Induced Cytotoxicity through Regulation of the Nrf2/HO-1 Signaling
Journal of Microbiology and Biotechnology
2023 .05
-
Engineering TCA Cycle for Renewable Production of Fumaric Acid by Escherichia coli
한국미생물학회 학술대회논문집
2016 .04
-
Accurate Determination of Short-Chain Fatty Acids and TCA Cycle Intermediates in Human Plasma by GC-MS/MS Combined with Lyophilization and Derivatization
한국분석과학회 학술대회
2021 .11
-
HT22 해마세포의 oxidative toxicity에 대한 천문동 유래 에탄올추출물의 보호 효과
생명과학회지
2016 .12
-
Lactoferrin Protects Human Mesenchymal Stem Cells from Oxidative Stress-Induced Senescence and Apoptosis
Journal of Microbiology and Biotechnology
2017 .01
-
Genetic Crosstalk between DNA Damage Repair Pathways and Oxidative Stress Responses for Maintenance of Genome Stability
한국미생물학회 학술대회논문집
2016 .04
-
Protective effect of Cordyceps militaris against hydrogen peroxide-induced oxidative stress in vitro
Nutrition Research and Practice
2019 .08
-
Protective effect of Cordyceps militaris against hydrogen peroxide-induced oxidative stress in vitro
Nutrition Research and Practice
2019 .08
-
Assessing the progression of gastric cancer via profiling of SCFAs and TCA cycle intermediates in human plasma using GC-MS/MS
한국분석과학회 학술대회
2022 .05
-
Assessing the progression of gastric cancer via profiling of SCFAs and TCA cycle intermediates in human plasma using GC-MS/MS
한국분석과학회 학술대회
2022 .05
-
Changes of lysosome by L-serine in rotenone-treated hippocampal neurons
한국현미경학회지
2023 .01
-
Apigenin Ameliorates Oxidative Stress-induced Neuronal Apoptosis in SH-SY5Y Cells
한국미생물·생명공학회지
2021 .01
-
망막색소상피세포에서 감초 추출물의 산화적 스트레스에 의한 DNA 손상 및 apoptosis 유발의 차단 효과
생명과학회지
2019 .11
-
Picropodophyllotoxin Induces G1 Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer Cells via ROS Generation and Activation of p38 MAPK Signaling Pathway
Journal of Microbiology and Biotechnology
2021 .12
-
nthocyanins Inhibits Oxidative Injury in Human Retinal Pigment Epithelial ARPE-19 Cells via Activating Heme Oxygenase-1
Journal of Microbiology and Biotechnology
2024 .03
-
1-Methoxylespeflorin G11 Protects HT22 Cells from Glutamate-Induced Cell Death through Inhibition of ROS Production and Apoptosis
Journal of Microbiology and Biotechnology
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0