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논문 기본 정보

자료유형
학술저널
저자정보
심재원 (전남대병원) 배인호 (전남대학교) 정명호 (전남대학교병원) 박대성 (전남대학교병원) 임경섭 (한국생명공학연구원) 김재운 (전남대병원) 김문기 (전남대학교) 김정하 (전남대학교) 김주한 (전남대학교병원) 심두선 (전남대학교병원)
저널정보
대한금속·재료학회 Metals and Materials International Metals and Materials International Vol.26 No.10
발행연도
2020.1
수록면
1,455 - 1,462 (8page)

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This study was performed to evaluate the effects of a diamond-like carbon (DLC) layer on the biological properties of a pretreatedtitanium dioxide (TiO2) coronary stent surface. TiO2and DLC were coated onto a cobalt-chromium stent surface inconsecutive order using the plasma-enhanced chemical vapor deposition method (TiO2/DLC). To investigate the effect ofTiO2,a group treated only with DLC was also prepared as a control. The surface characteristics were investigated by SEM,ESCA, AFM, and contact angle analyses. To estimate the effect of surface modification on biological response, endothelialcell migration was carried out. As a result, cracking of the coating layer on the strut curved portion in the DLC group wasrestored in the TiO2/DLC group. ESCA result showed that the peaks sp2 and sp3 were slightly shifted and higher in the TiO2/DLC group. The surface roughness average was highly increased in the TiO2/DLC group (Ra; 18.033) compared to the BMS(Ra; 9.258) and DLC groups (Ra; 10.144). By the increment of Ra, the surface property became hydrophilic in the TiO2/DLC group (39.8° ± 5.88°) compared to the non-treated (72.7° ± 2.24°) and DLC (78.6° ± 2.24°) groups. Endothelial cellmigration was significantly increased in the TiO2/DLC group (68.9 ± 13.52%) compared to the non-treated (5.4 ± 3.14%) andDLC groups (22.3 ± 8.22%). Therefore, the improvement of surface properties and endothelial cell migration in the TiO2/DLC group could improve the physiological response in the human body.

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