지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 925 - 932 (8page)
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초록· 키워드
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Background: Concomitant papillary thyroid cancer (PTC) and hyperparathyroidism (HPT) have been reported in several studies. Our study aimed to investigate the incidence of concomitant PTC in HPT patients upon preoperative diagnosis and present a clinical opinion on detecting thyroid malignancy in case of parathyroidectomy. Methods: Patients who underwent parathyroidectomy between January 2009 and December 2019 in two medical centers were included. Of the 279 participants 154 were diagnosed as primary hyperparathyroidism (pHPT) and 125 as secondary hyperparathy roidism (sHPT). The incidence of concomitant PTC and its clinical characteristics were compared with 98 patients who underwent thyroidectomy and were diagnosed with classical PTC during the same period. Results: Concurrent PTC was detected in 14 patients (9.1%) with pHPT and in nine patients (7.2%) with sHPT. Ten (71.4%) and seven (77.8%) PTCs were microcarcinomas in the pHPT and sHPT cases respectively. In the pHPT patients, vitamin D was lower in the pHPT+PTC group (13.0±3.7 ng/mL) than in the pHPT-only group (18.5±10.4 ng/mL; P=0.01). Vitamin D levels were also lower in the sHPT+PTC group (12.3±5.6 ng/mL) than in the sHPT-only group (18.0±10.2 ng/mL; P=0.12). In the concomitant PTC group, lymph node ratio was higher than in the classical PTC group (P=0.00). Conclusion: A high prevalence of concomitant PTC was seen in patients with pHPT and sHPT. Those concomitant PTCs were mostly microcarcinomas and had more aggressive features, suggesting that efforts should be made to detect concomitant malignancies in the preoperative parathyroidectomy evaluation.
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참고문헌 (36)
참고문헌 신청
Heath DA / 1989 / Primary hyperparathyroidism. Clinical presentation and factor influencing clinical management / Endocrinol Metab Clin North Am 18:631~646
Darba J / 2020 / Epidemiology and management of parathyroid gland disorders in Spain over 15 years : a retrospective multicentre analysis / PLoS One 15:e0230130
Collier A / 2017 / Primary hyperparathyroidism : increasing prevalence, social deprivation, and surgery / Endocr Res 42:31~35
Fraser WD / 2009 / Hyperparathyroidism / Lancet 374:145~158
Pitt SC / 2009 / Secondary and tertiary hyper-parathyroidism, state of the art surgical management / Surg Clin North Am 89:1227~1239
Darba J / 2020 / Epidemiology and management of parathyroid gland disorders in Spain over 15 years : a retrospective multicentre analysis / PLoS One 15:e0230130
Collier A / 2017 / Primary hyperparathyroidism : increasing prevalence, social deprivation, and surgery / Endocr Res 42:31~35
Fraser WD / 2009 / Hyperparathyroidism / Lancet 374:145~158
Pitt SC / 2009 / Secondary and tertiary hyper-parathyroidism, state of the art surgical management / Surg Clin North Am 89:1227~1239
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