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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 257 - 272 (16page)
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초록· 키워드
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Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and nonalcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in the intestine by gut bacteria. Bile acids are nutrient sensors and metabolic integrators that regulate lipid, glucose, and energy homeostasis by activating nuclear farnesoid X receptor and membrane Takeda G protein-coupled receptor 5. Bile acids control gut bacteria overgrowth, species population, and protect the integrity of the intestinal barrier. Gut bacteria, in turn, control circulating bile acid composition and pool size. Dysregulation of bile acid homeostasis and dysbiosis causes diabetes and obesity. Targeting bile acid signaling and the gut microbiome have therapeutic potential for treating diabetes, obesity, and non-alcoholic fatty liver disease.
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등록된 정보가 없습니다.
참고문헌 (136)
참고문헌 신청
Rowley WR / 2017 / Diabetes 2030 : insights from yesterday, today, and future trends / Popul Health Manag 20:6~12
Finkelstein EA / 2012 / Obesity and severe obesity forecasts through 2030 / Am J Prev Med 42:563~570
Targher G / 2016 / Risk of type 2 diabetes in patients with non-alcoholic fatty liver disease : causal association or epiphenomenon / Diabetes Metab 42:142~156
Younossi Z / 2018 / Global burden of NAFLD and NASH : trends, predictions, risk factors and prevention / Nat Rev Gastroenterol Hepatol 15:11~20
Lonardo A / 2018 / Hypertension, diabetes, atherosclerosis and NASH : cause or consequence / J Hepatol 68:335~352
Finkelstein EA / 2012 / Obesity and severe obesity forecasts through 2030 / Am J Prev Med 42:563~570
Targher G / 2016 / Risk of type 2 diabetes in patients with non-alcoholic fatty liver disease : causal association or epiphenomenon / Diabetes Metab 42:142~156
Younossi Z / 2018 / Global burden of NAFLD and NASH : trends, predictions, risk factors and prevention / Nat Rev Gastroenterol Hepatol 15:11~20
Lonardo A / 2018 / Hypertension, diabetes, atherosclerosis and NASH : cause or consequence / J Hepatol 68:335~352
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