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자료유형
학술저널
저자정보
유지희 (고려대학교) 한경도 (가톨릭대학교) 박상현 (가톨릭대학교(성의교정)) 조한나 (연세대학교) 이다영 (Korea University) Jin Wook Kim (Korea University) Ji A Seo (Korea University) Sin-Gon Kim (Korea University) Sei Hyun Baik (Korea University) Yong Gyu Park (TheCatholic University of Korea) Kyung Mook Choi (Korea University) Seon Mee Kim (Korea University) Nan Hee Kim (Korea University)
저널정보
대한당뇨병학회 Diabetes and Metabolism Journal Diabetes and Metabolism Journal Vol.44 No.1
발행연도
2020.1
수록면
113 - 124 (12page)

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Background: Diabetes mellitus is associated with an increased risk of dementia. We aimed to comprehensively analyze the incidence and risk factors for dementia and young-onset dementia (YOD) in diabetic patients in Korea using the National Health Insurance Service data. Methods: Between January 1, 2009 and December 31, 2012, a total of 1,917,702 participants with diabetes were included and followed until the date of dementia diagnosis or until December 31, 2015. We evaluated the incidence and risk factors for all dementia, Alzheimer’s disease (AD), and vascular dementia (VaD) by Cox proportional hazards analyses. We also compared the impact of risk factors on the occurrence of YOD and late-onset dementia (LOD). Results: During an average of 5.1 years of follow-up, the incidence of all types of dementia, AD, or VaD was 9.5, 6.8, and 1.3/1,000 person-years, respectively, in participants with diabetes. YOD comprised 4.8% of all dementia occurrence, and the ratio of AD/ VaD was 2.1 for YOD compared with 5.5 for LOD. Current smokers and subjects with lower income, plasma glucose levels, body mass index (BMI), and subjects with hypertension, dyslipidemia, vascular complications, depression, and insulin treatment developed dementia more frequently. Vascular risk factors such as smoking, hypertension, and previous cardiovascular diseases were more strongly associated with the development of VaD than AD. Low BMI and a history of stroke or depression had a stronger influence on the development of YOD than LOD. Conclusion: The optimal management of modifiable risk factors may be important for preventing dementia in subjects with diabetes mellitus.

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