지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 555 - 564 (10page)
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초록· 키워드
오류제보하기
Purpose: Volumetry is used in polycystic kidney and liver diseases (PKLDs), including autosomal dominant polycystic kidney disease (ADPKD), to assess disease progression and drug efficiency. However, since no rapid and accurate method for volumetry has been developed, volumetry has not yet been established in clinical practice, hindering the development of therapies for PKLD. This study presents an artificial intelligence (AI)-based volumetry method for PKLD. Materials and Methods: The performance of AI was first evaluated in comparison with ground-truth (GT). We trained a V-net-based convolutional neural network on 175 ADPKD computed tomography (CT) segmentations, which served as the GT and were agreed upon by 3 experts using images from 214 patients analyzed with volumetry. The dice similarity coefficient (DSC), interobserver correlation coefficient (ICC), and Bland–Altman plots of 39 GT and AI segmentations in the validation set were compared. Next, the performance of AI on the segmentation of 50 random CT images was compared with that of 11 PKLD specialists based on the resulting DSC and ICC. Results: The DSC and ICC of the AI were 0.961 and 0.999729, respectively. The error rate was within 3% for approximately 95% of the CT scans (error<1%, 46.2%; 1%≤error<3%, 48.7%). Compared with the specialists, AI showed moderate performance. Furthermore, an outlier in our results confirmed that even PKLD specialists can make mistakes in volumetry. Conclusions: PKLD volumetry using AI was fast and accurate. AI performed comparably to human specialists, suggesting its use may be practical in clinical settings.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Harris PC / 1999 / Autosomal dominant polycystic kidney disease : clues to pathogenesis / Hum Mol Genet 8:1861~1866
Bae KT / 2006 / Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease : the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort / Clin J Am Soc Nephrol 1:64~69
Chauveau D / 2000 / Liver involvement in autosomal-dominant polycystic kidney disease : therapeutic dilemma / J Am Soc Nephrol 11:1767~1775
Kim H / 2015 / Clinical correlates of mass effect in autosomal dominant polycystic kidney disease / PLoS One 10:e0144526
Ryu H / 2017 / Total kidney and liver volume is a major risk factor for malnutrition in ambulatory patients with autosomal dominant polycystic kidney disease / BMC Nephrol 18:22
Bae KT / 2006 / Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease : the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort / Clin J Am Soc Nephrol 1:64~69
Chauveau D / 2000 / Liver involvement in autosomal-dominant polycystic kidney disease : therapeutic dilemma / J Am Soc Nephrol 11:1767~1775
Kim H / 2015 / Clinical correlates of mass effect in autosomal dominant polycystic kidney disease / PLoS One 10:e0144526
Ryu H / 2017 / Total kidney and liver volume is a major risk factor for malnutrition in ambulatory patients with autosomal dominant polycystic kidney disease / BMC Nephrol 18:22
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