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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 340 - 348 (9page)
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초록· 키워드
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Purpose: MicroRNAs (miRNAs) are small non-coding RNAs and are involved in the development, proliferation, and pathogenesis of prostate cancer (PCa). Urinary miRNAs are promising non-invasive biomarkers for PCa diagnosis because of their stability in urine. Here, we evaluated the diagnostic value of urinary miR-1913 to miR-3659 ratio in PCa patients and benign prostate hyperplasia (BPH) controls. Materials and Methods: Candidate miRNAs were identified from urinary microarray data and tested by real-time PCR. The urinary miR-1913 to miR-3659 expression ratio was selected and tested in 83 urine samples (44 PCa and 39 BPH) to confirm its validity as a non-invasive diagnostic biomarker for PCa. Results: The expression ratio of urinary miR-1913 to miR-3659 was significantly higher in PCa than in BPH (p=0.002) and showed a higher area under the receiver operating characteristic curve than prostate-specific antigen (PSA; 0.821 vs. 0.518) in patients within the PSA gray zone (tPSA: 3–10 ng/mL), with sensitivity of 75.0% and specificity of 78.6% (p=0.003). Conclusions: The urinary miR-1913 to miR-3659 expression ratio was increased in PCa and may serve as a useful supplemental biomarker to PSA for the diagnosis of PCa, particularly in patients within the PSA gray zone.
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참고문헌 (30)
참고문헌 신청
Kumar-Sinha C / 2008 / Recurrent gene fusions in prostate cancer / Nat Rev Cancer 8:497~511
Jason M. Hafron / 2017 / New developments in prostate cancer screening using a novel cancer-specific, non-PSA biomarker assay derived from autoantibody signatures / Journal of Medicine and Therapeutics 1(4)
Liu DF / 2012 / MicroRNA expression profile analysis reveals diagnostic biomarker for human prostate cancer / Asian Pac J Cancer Prev 13:3313~3317
Bartel DP / 2004 / MicroRNAs : genomics, biogenesis, mechanism, and function / Cell 116:281~297
Mattie MD / 2006 / Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies / Mol Cancer 5:24
Jason M. Hafron / 2017 / New developments in prostate cancer screening using a novel cancer-specific, non-PSA biomarker assay derived from autoantibody signatures / Journal of Medicine and Therapeutics 1(4)
Liu DF / 2012 / MicroRNA expression profile analysis reveals diagnostic biomarker for human prostate cancer / Asian Pac J Cancer Prev 13:3313~3317
Bartel DP / 2004 / MicroRNAs : genomics, biogenesis, mechanism, and function / Cell 116:281~297
Mattie MD / 2006 / Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies / Mol Cancer 5:24
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