지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 120 - 134 (15page)
이용수
초록· 키워드
오류제보하기
Background: Larger middle molecules are important substances associated with cardiovascular complications in end- stage renal disease. Unfortunately, larger middle molecules are not reliably removed by a high-flux dialyzer. A medium cut-off (MCO) membrane could effectively remove larger middle molecules. This study aimed to identify the long -term effect of the MCO membrane for changes of larger middle molecules. Methods: Thirty-four patients were prospectively analyzed for 12 months. The enrolled patients were divided into control and MCO groups. We measured the plasma levels of growth differentiation factor 15, sclerostin, and fibroblast growth factor 23 in larger middle molecules and those of biomarkers including small solutes. Single-pool Kt/V (spKt/V) and reduction ratios also were evaluated. Results: Plasma sclerostin did not increase significantly in patients using the MCO dialyzer (135.3 [–637.7 to 908.3], p = 0.715). And there was a significant difference in change of plasma sclerostin level between the two groups (–1,646.9 [–3,015.2 to –278.7], p = 0.033). Furthermore, a negative association between calcium and sclerostin was not observed in the MCO group (r = –0.142, p = 0.587). Solute clearance of larger middle molecules in the MCO group was significantly higher. Moreover, spKt/V values for patients in the MCO group were significantly increased without albumin loss. Values are presented as mean (95% confidence interval [CI]) or adjusted mean (95% CI). Conclusion: The MCO dialyzer can increase dialytic adequacy and suppress the increase in plasma sclerostin level without significant albumin loss in patients with end-stage renal disease.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Zickler D / 2017 / Medium cut-off(MCO)membranes reduce inflammation in chronic dialysis patients : a randomized controlled clinical trial / PLoS One 12:e0169024
Liabeuf S / 2012 / Plasma beta-2microglobulin is associated with cardiovascular disease in uremic patients / Kidney Int 82:1297~1303
García-Prieto A / 2018 / Evaluation of the efficacy of a medium cut-off dialyser and comparison with other high-flux dialysers in conventional haemodialysis and online haemodiafiltration / Clin Kidney J 11:742~746
Glorieux G / 2011 / New uremic toxins : which solutes should be removed / Contrib Nephrol 168:117~128
Wolley M / 2018 / Exploring the clinical relevance of providing increased removal of large middle molecules / Clin J Am Soc Nephrol 13:805~814
Liabeuf S / 2012 / Plasma beta-2microglobulin is associated with cardiovascular disease in uremic patients / Kidney Int 82:1297~1303
García-Prieto A / 2018 / Evaluation of the efficacy of a medium cut-off dialyser and comparison with other high-flux dialysers in conventional haemodialysis and online haemodiafiltration / Clin Kidney J 11:742~746
Glorieux G / 2011 / New uremic toxins : which solutes should be removed / Contrib Nephrol 168:117~128
Wolley M / 2018 / Exploring the clinical relevance of providing increased removal of large middle molecules / Clin J Am Soc Nephrol 13:805~814
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hyperglycemia increases the expression levels of sclerostin in a reactive oxygen species- and tumor necrosis factor-alpha-dependent manner
Journal of Periodontal & Implant Science
2015 .01
-
Decreased Serum Level of Sclerostin in Older Adults with Sarcopenia
Endocrinology and Metabolism
2022 .06
-
Gingival crevicular fluid levels of sclerostin in chronic periodontitis and healthy subjects
대한구강악안면외과학회지
2018 .01
-
Romosozumab for the treatment of osteoporosis
Osteoporosis and Sarcopenia
2018 .01
-
Serum Sclerostin Levels in Patients with Human Immunodeficiency Virus Infection and Their Association with Bone Turnover Markers and Bone Mineral Densitometry
대한골대사학회지
2016 .01
-
Socio-demographic disparities in the eating behaviour of Malaysian children during the COVID-19 lockdown
Osong Public Health and Research Persptectives
2021 .01
-
Orthodontic Tooth Movement-Induced Sclerostin in Periodontal Ligament
대한체질인류학회 학술대회 연제 초록
2021 .05
-
Sclerostin as a Putative Myokine in Sarcopenia
Endocrinology and Metabolism
2022 .06
-
Evaluation of bone mineral density and bone strength in autochthonous transgenic model mice for diabetes mellitus (Akita mice)
Osteoporosis and Sarcopenia
2015 .01
-
Romosozumab: 새로운 골다공증 치료제
대한골절학회지
2021 .10
-
Effects of Single Vitamin D3 Injection (200,000 Units) on Serum Fibroblast Growth Factor 23 and Sclerostin Levels in Subjects with Vitamin D Deficiency
Endocrinology and Metabolism
2017 .01
-
Self-checking Type, Repetitive, Education Efficacy for Temporomandibular Disorder Patients
Journal of Oral Medicine and Pain
2015 .06
-
Current characteristics of dialysis therapy in Korea: 2015 registry data focusing on elderly patients
Kidney Research and Clinical Practice
2016 .01
-
Single Molecule Method for Molecular Biology
International Journal of Oral Biology
2018 .01
-
Trends in clinical outcomes of older hemodialysis patients: data from the 2023 Korean Renal Data System (KORDS)
Kidney Research and Clinical Practice
2024 .05
-
Malaysia Healthcare Early Response in Combatting COVID-19 Pandemic in 2020
Korean Journal of Family Medicine
2021 .11
-
The effect of romosozumab on orthodontic tooth movement in ovariectomized rats
한국실험동물학회 학술발표대회 논문집
2023 .02
-
Factors Associated with Clinical Outcomes of Palliative Stenting for Malignant Colonic Obstruction
Gut and Liver
2021 .01
-
Efficacy and Toxicity of Mammalian Target Rapamycin Inhibitors in Patients with Metastatic Renal Cell Carcinoma with Renal Insufficiency: The Korean Cancer Study Group GU 14-08
Cancer Research and Treatment
2016 .01
-
Measurement and Estimation of Renal Size by Computed Tomography in Korean Children
Journal of Korean Medical Science
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0