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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 8 - 13 (6page)
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초록· 키워드
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Objective: Intrauterine inflammation caused by chorioamnionitis has been related with various perinatal morbidities which increase the risk of bronchopulmonary dysplasia (BPD). C-reactive protein (CRP) is a well known biomarker of inflammation. We aimed to investigate the relationship between histological chorioamnionitis (HCA) and BPD, and also to observe the changes of CRP in BPD. Methods: Low-birth-weight infants (LBWIs) admitted to the neonatal intensive care unit between January 2011 and October 2017 were reviewed. Perinatal morbidities associated with BPD including maternal HCA were observed. Also, changes of CRP were analyzed. Results: A total of 584 LBWIs were analyzed and 168 (28.8%) had HCA and 46 (7.9%) had BPD. The development of BPD was associated with gestational age, birth weight, 1 and 5 minutes Apgar scores, the presence of preterm premature rupture of membrane, prenatal antibiotics, respiratory distress syndrome (RDS), ventilator application, early onset sepsis, necrotizing enterocolitis, intraventricular hemorrhage, retinopathy of prematurity, patent ductus arteriosus and HCA. The multiple logistic regression model for BPD showed that the risk factors of BPD were lower gestational age, lower birth weight, patent ductus arteriosus (PDA). Chorioamnionitis was not a significant risk factor for BPD (aOR, 1.477; 95% CI, 0.376-5.806). Infants with BPD were likely to have higher CRP on day 0 and day 7. Conclusion: Our study suggests that the primary risk factors of BPD in LBWIs are lower gestational age, lower birth weight, RDS, ventilator application and PDA rather than HCA. In infants with BPD, CRP was significantly higher on day 0 and day 7.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Speer CP / 2006 / Inflammation and bronchopulmonary dysplasia: a continuing story / Semin Fetal Neonatal Med 11:354~362
Kim CJ / 2015 / Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance / Am J Obstet Gynecol 213(4 Suppl):S29~S52
Malavolti AM / 2018 / Bronchopulmonary dysplasia-impact of severity and timing of diagnosis on neurodevelopment of preterm infants: a retrospective cohort study / BMJ Paediatr Open 2:e000165
You JY / 2017 / Readmission of children with bronchopulmonary dysplasia in the first 2 years of life: a clinical analysis of 121 cases / Zhongguo Dang Dai Er Ke Za Zhi 19:1056~1060
Bozzetto S / 2016 / Health-related quality of life in adolescent survivors of bronchopulmonary dysplasia / Respirology 21:1113~1117
Kim CJ / 2015 / Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance / Am J Obstet Gynecol 213(4 Suppl):S29~S52
Malavolti AM / 2018 / Bronchopulmonary dysplasia-impact of severity and timing of diagnosis on neurodevelopment of preterm infants: a retrospective cohort study / BMJ Paediatr Open 2:e000165
You JY / 2017 / Readmission of children with bronchopulmonary dysplasia in the first 2 years of life: a clinical analysis of 121 cases / Zhongguo Dang Dai Er Ke Za Zhi 19:1056~1060
Bozzetto S / 2016 / Health-related quality of life in adolescent survivors of bronchopulmonary dysplasia / Respirology 21:1113~1117
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