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박천강; 이아진; 김상경; 전창호; 서헌석

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자료유형: 학술저널

저자정보: 박천강 (대구가톨릭대학교 의과대학 진단검사의학교실) 이아진 (대구가톨릭대학교 의과대학 진단검사의학교실) 김상경 (대구가톨릭대학교 의과대학 진단검사의학교실) 전창호 (대구가톨릭대학교 의과대학 진단검사의학교실) 서헌석 (대구가톨릭대학교 의과대학 진단검사의학교실)

저널정보: 대한수혈학회 대한수혈학회지 대한수혈학회지 제30권 제2호

발행연도: 2019.1

수록면: 148 - 155 (8page)

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연구방법

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Background: Therapeutic plasma exchange (TPE) is used to remove pathologic substances involved in various disease etiologies. The use of TPE is increasing steadily in a variety of disease. This study analyzed the incidence, type and severity of adverse events (AE) according to the initial TPE of each patient in a single center. The risk factors for AE of TPE were also elucidated. Methods: The medical and laboratory records of patients, who received TPE from January 2014 to December 2018, were reviewed retrospectively. The signs or symptoms during and after TPE were analyzed. Results: TPE sessions were performed on 95 patients. The mean age was 53.3 years and men comprised 63.2%. The most common indication for TPE was desensitization for ABO-incompatible liver transplantation (ABO-i LT) (N=56, 58.9%). A total of 27 patients (28.4%) experienced AE during the initial TPE. The types of AE were allergic reactions (N=14, 14.7%), anaphylactic reaction (N=3, 11.1%), hypotension (N=5, 5.3%), hypocalcemic reaction (N=4, 4.2%), and febrile nonhemolytic reaction (N=1, 1.1%). The severities of AE were evaluated as mild in eight procedures (8.4 %), moderate in seventeen (17.9 %), and severe in two (2.1 %). Multivariable logistic regression analysis showed that the desensitization for ABO-i LT (odds ratio (OR), 2.08; 95% CI, 1.03∼4.22) and the amount of FFP (OR, 1.07; 95% CI, 1.01∼1.09) were associated with a higher incidence of AE. Conclusion: TPE can be performed under careful patient monitoring to provide prompt intervention, particularly in patients with desensitization of ABO-i LT using FFP. (Korean J Blood Transfus 2019;30:148-155)

#Therapeutic plasma exchange #Risk factors #Adverse events #Allergic reactions

참고문헌 (15)

참고문헌 신청

Lockwood CM / 1975 / Recovery from Goodpasture’s syndrome after immunosuppressive treatment and plasmapheresis / Br Med J 2:252~254

Schwartz J / 2016 / Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: the seventh special issue / J Clin Apher 31:149~162

Schwartz J / 2013 / Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: the sixth special issue / J Clin Apher 28:145~284

Song EY / 2008 / Establishment of a national on-line registry for apheresis in Korea / Transfus Apher Sci 38:93~100

김지은 / 2016 / Initial ABO Antibody Titer as a Variable for Estimating Number of Therapeutic Plasma Exchange prior to ABO Incompatible Kidney Transplantation / 대한수혈학회지 27(1):22~30

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