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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objective：Declines in naming ability and semantic memory are well-known features of early Alzheimer’s disease (AD). We developed a new screening algorithm for AD using two brief language tests : the Categorical Fluency Test (CFT) and 15-item Boston Naming Test (BNT15). Methods：We administered the CFT, BNT15, and Mini-Mental State Examination (MMSE) to 150 AD patients with a Clinical Dementia Rating of 0.5 or 1 and to their age- and gender-matched cognitively normal controls. We developed a composite score for screening AD (LANGuage Composite score, LANG-C) that comprised demographic characteristics, BNT15 subindices, and CFT subindices. We compared the diagnostic accuracies of the LANG-C and MMSE using receiver operating curve analysis. Results：The LANG-C was calculated using the logit of test scores weighted by their coefficients from forward stepwise logistic regression models : logit (case)=12.608-0.107×age+1.111×gender+0.089×education-0.314×HS1st-0.362×HS2nd+0.455×perseveration+ 1.329×HFCR2nd-0.489×MFCR1st-0.565×LFCR3rd. The area under the curve of the LANG-C for diagnosing AD was good (0.894, 95% confidence interval=0.853-0.926 ; sensitivity=0.787, specificity=0.840), although it was smaller than that of the MMSE. Conclusion：The LANG-C, which is easy to automate using PC or smart devices and to deliver widely via internet, can be a good alternative for screening AD to MMSE.
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참고문헌 (21)
참고문헌 신청
Weintraub S / 2012 / The neuropsychological profile of Alzheimer disease / Cold Spring Harb Perspect Med 2:a006171
Balthazar ML / 2008 / Semantic error patterns on the Boston Naming Test in normal aging, amnestic mild cognitive impairment, and mild Alzheimer’s disease: is there semantic disruption / Neuropsychology 22:703~709
Verma M / 2012 / Semantic memory and language dysfunction in early Alzheimer’s disease: a review / Int J Geriatr Psychiatry 27:1209~1217
박경애 / 2011 / 알츠하이머병과 경도인지장애 환자에서 이름대기 검사 수행 능력의 차이 / Annals of geriatric medicine and research 15(3):135~143
Kim H / 1997 / Naming deficits in patients with dementia of the Alzheimer type: error analysis of Korean version-Boston Naming Test / J Korean Neurol Assoc 15:1012~1021
Balthazar ML / 2008 / Semantic error patterns on the Boston Naming Test in normal aging, amnestic mild cognitive impairment, and mild Alzheimer’s disease: is there semantic disruption / Neuropsychology 22:703~709
Verma M / 2012 / Semantic memory and language dysfunction in early Alzheimer’s disease: a review / Int J Geriatr Psychiatry 27:1209~1217
박경애 / 2011 / 알츠하이머병과 경도인지장애 환자에서 이름대기 검사 수행 능력의 차이 / Annals of geriatric medicine and research 15(3):135~143
Kim H / 1997 / Naming deficits in patients with dementia of the Alzheimer type: error analysis of Korean version-Boston Naming Test / J Korean Neurol Assoc 15:1012~1021
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