Use of Topical Tranexamic Acid to Reduce Blood Loss in Single-Level Transforaminal Lumbar Interbody Fusion

Mallepally Abhinandan Reddy; Mahajan Rajat; Rustagi Tarush; Goel Shakti Amar; Das Kalidutta; Chhabra Harvinder Singh

추천

검색

자료유형: 학술저널

저자정보: Mallepally Abhinandan Reddy (Indian Spinal Injuries Centre New Delhi) Mahajan Rajat (Indian Spinal Injuries Centre New Delhi India) Rustagi Tarush (Indian Spinal Injuries Centre New Delhi India) Goel Shakti Amar (Indian Spinal Injuries Centre New Delhi India) Das Kalidutta (Indian Spinal Injuries Centre New Delhi India) Chhabra Harvinder Singh (Indian Spinal Injuries Centre New Delhi India)

저널정보: 대한척추외과학회 Asian Spine Journal Asian Spine Journal Vol.14 No.5

발행연도: 2020.1

수록면: 593 - 600 (8page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Study Design: Nonrandomized, prospective, and case-controlled study.Purpose: To evaluate the efficacy and cost-effectiveness of topically applied tranexamic acid (TXA) during different phases of spine surgery.Overview of Literature: Perioperative blood loss is the leading cause of postoperative anemia associated with prolonged stays in hospital and long recovery times. The direct and indirect costs involved pose a significant economic challenge in developing countries. There is no consensus for topical use of tranexamic acid in spine surgery.Methods: Patients requiring a single-level TLIF were divided into 2 groups. In the TXA group (n=75), the wound surface was soaked with TXA (1 g in 100 mL saline solution) for 3 minutes after exposure, after decompression, and before wound closure, and in the control group (n=175) using only saline. Intraoperative blood loss drain volume was recorded on each of the first 2 days immediately after surgery. An estimated cost analysis was made on the basis of the length of hospital stay and the blood transfusion.Results: IBL for the control group was 783.33±332.71 mL and for intervention group 410.57±189.72 mL (p <0.001). The operative time for control group was 3.24±0.38 hours and for intervention group 2.99±0.79 hours (p <0.695). Hemovac drainage on days 1 and 2 for control group was 167.10±53.83 mL and 99.33±37.5 mL, respectively, and for intervention group 107.03±44.37 mL and 53.38±21.99 mL, respectively (p <0.001). The length of stay was significantly shorter in the intervention group (4.8±1.1 days) compared to control group (7.0±2.3 days). The cost of treatment in the intervention group was US dollar (USD) 4,552.57±1,222.6 compared with that in the control group USD 6,529.9±1,505.04.Conclusions: Topical TXA is a viable, cost-effective method of decreasing perioperative blood loss in major spine surgery with fewer overall complications than other methods. Further studies are required to find the ideal dosage and timing.

#Spine surgery #Topical #Tranexamic acid #Surgical blood loss #Cost-effectiveness

참고문헌 (29)

참고문헌 신청

Huang YH / 2015 / Significant blood loss in lumbar fusion surgery for degenerative spine / World Neurosurg 84:780~785

Kumar A / 2009 / Perioperative management of anemia : limits of blood transfusion and alternatives to it / Cleve Clin J Med 76(Suppl 4):S112~S118

Dutton RP / 2004 / Controlled hypotension for spinal surgery / Eur Spine J 13(Suppl 1):S66~S71

Gill JB / The use of antifibrinolytic agents in spine surgery: a meta-analysis / J Bone Joint Surg Am 90:2399~2407

Yerneni K / 2019 / Topical tranexamic acid in spinal surgery : a systematic review and meta-analysis / J Clin Neurosci 61:114~119

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

Mallepally Abhinandan Reddy

소속기관 Indian Spinal Injuries Centre New Delhi

주요연구분야 의약학 > 임상의학 > 정형외과학

논문수 5 이용수 0

Mahajan Rajat