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논문 기본 정보

자료유형
학술저널
저자정보
Min Keun Kim (Yonsei University) Han Wul Shin (Department of Nephrology Yonsei University Wonju College of Medicine Wonju Korea) You Jin Kim (Department of Nephrology Yonsei University Wonju College of Medicine Wonju Korea) Jae Won Yang (Department of Nephrology Yonsei University Wonju College of Medicine Wonju Korea) Jae Seok Kim (Department of Nephrology Yonsei University Wonju College of Medicine Wonju Korea) Byoung Geun Han (Division of Nephrology Department of Internal Medicine Yonsei University Wonju College of Medicine) Seung Ok Choi (Division of Nephrology Department of Internal Medicine Yonsei University Wonju College of Medicine) 이준영 (Division of Nephrology Department of Internal Medicine Yonsei University Wonju College of Medicine)
저널정보
전해질고혈압연구회 Electrolytes & Blood Pressure Electrolytes & Blood Pressure Vol.17 No.1
발행연도
2019.1
수록면
7 - 15 (9page)

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Background: Alcoholic ketoacidosis(AKA) is known as a benign disease, but the related mortality reported in Korea is high. Acidosis and alcohol change the immunity profile, and these changes can be identified early using the delta neutrophil index(DNI). We aimed to evaluate the use of DNI and other standard laboratory parameters as predictors of prognosis in AKA patients. Methods: One hundred eighteen males with AKA were evaluated at the Wonju Severance Christian hospital between 2009 and 2014. We performed a retrospective analysis of demographic, clinical, and laboratory parameters data. Receiver operating characteristic curves(ROC) and multivariate Cox regression was used to identify renal survival and mortality. Results: Survival patients had lower initial DNI levels than non-survival patients(4.8±6.4 vs 11.4±12.5, p<0.001). In multivariate-adjusted Cox regre- ssion analysis, higher initial increased DNI(HR 1.044, 95% CI 1.003-1.086, p=0.035), and lower initial pH(HR 0.044, 95% CI 0.004-0.452, p=0.008) were risk factors for dialysis during hospitalization. Further, higher initial DNI level(HR 1.037; 95% CI 1.006-1.069; p=0.018), lower initial pH(HR 0.049; 95% CI 0.008-0.312; p=0.001) and lower initial glomerular filtration rate(GFR)(HR 0.981; 95% CI 0.964-0.999; p=0.033) were predictors of mortality. A DNI value of 4.5% was selected as the cut-off value for poor prognosis and Kaplan-Meier plots showed that AKA patients with an initial level DNI ≥4.5% had lower cumulative survival rates than AKA patients with an initial DNI <4.5%. Conclusion: Increased initial serum DNI levels may help to predict renal sur- vival and prognosis in male AKA patients.

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