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논문 기본 정보

자료유형
학술저널
저자정보
류지원 (Department of Internal Medicine Cheju Halla General Hospital Cheju Korea) Ran-hui Cha (Department of Internal Medicine National Medical Center Seoul Korea) Hajeong Lee (Division of Nephrology Department of Internal Medicine Seoul National University Hospital) Yon Su Kim (Department of Internal Medicine Seoul National University College of Medicine) Jung Pyo Lee (Seoul National University Boramae Medical Center) Young Rim Song (Department of Internal Medicine Hallym University Sacred Heart Hospital) 김성균 (한림대학교) Sejoong Kim (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National Universit)
저널정보
전해질고혈압연구회 Electrolytes & Blood Pressure Electrolytes & Blood Pressure Vol.17 No.2
발행연도
2019.1
수록면
36 - 44 (9page)

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Background: The 24-hour mean blood pressure (mBP) is the best predictor of organ damage; however, it is not easily applicable in clinical practice. The APrODiTe study suggested that systolic blood pressure (SBP) values at 7:00 AM and 9:30 PM were associated with the 24-hour mSBP in patients with chronic kidney disease (CKD). We investigated the association of the SBP values at these time-points with the renal outcomes in patients with diabetic CKD during 1-year follow-up. Methods: Ninety-six patients with diabetic CKD were included at 1-year follow-up. The renal outcomes were an increase in the random urine protein/creatinine ratio or estimated glomerular filtration rate (eGFR) deterioration, which means a decrease in eGFR ≥5 mL/min/1.73 m2 compared to the baseline values. Results: The baseline SBP values at 7:00 AM, and 9:30 PM, and the 24-hour mSBP were 135.6±24.9 mmHg, 141.7±25.6 mmHg, and 136.4±20.7 mmHg, respectively. The SBP values measured at the same time-points after 1 year were similar to those at baseline. The SBP at 7:00 AM was significantly associated with eGFR deterioration in the univariate and multivariate analyses (odds ratio [OR]: 1.032; 95% confidence interval [CI]: 1.006- 1.059; p=0.016). The SBP at 7:00AM and 24-hour mSBP did not show a concordant association with sustained proteinuria in the linear and logistic analyses. In the subgroup analysis, the association between the SBP at 7:00 AM and eGFR deterioration persisted in patients with CKD stage 3-5 (OR: 1.041; 95% CI: 1.010-1.073; p=0.010). Conclusion: The SBP at 7:00 AM, in addition to the 24-hour mSBP, is also associated with eGFR deterioration in patients with diabetic CKD, particularly in those with CKD stage 3-5.

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