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논문 기본 정보

자료유형
학술저널
저자정보
Lluís Mundet (Unitat d’Exploracions Funcionals Digestives Hospital de Mataró Consorci Sanitari del Maresme Mataró) Christopher Cabib (Unitat d’Exploracions Funcionals Digestives Hospital de Mataró Consorci Sanitari del Maresme Mataró) Omar Ortega (Unitat d’Exploracions Funcionals Digestives Hospital de Mataró Consorci Sanitari del Maresme Mataró) Laia Rofes (Unitat d’Exploracions Funcionals Digestives Hospital de Mataró Consorci Sanitari del Maresme Mataró) Noemí Tomsen (Unitat d’Exploracions Funcionals Digestives Hospital de Mataró Consorci Sanitari del Maresme Mataró) Sergio Marin (Unitat d’Exploracions Funcionals Digestives Hospital de Mataró Consorci Sanitari del Maresme Mataró) Carla Chacón (Unitat d’Exploracions Funcionals Digestives Hospital de Mataró Consorci Sanitari del Maresme Mataró) Pere Clavé (Unitat d’Exploracions Funcionals Digestives Hospital de Mataró Consorci Sanitari del Maresme Mataró)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.25 No.3
발행연도
2019.1
수록면
423 - 435 (13page)

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Background/AimsFecal incontinence (FI) is a prevalent condition among women. While biomechanical motor components have been thoroughlyresearched, anorectal sensory aspects are less known. We studied the pathophysiology of FI in community-dwelling women,specifically, the conduction through efferent/afferent neural pathways. MethodsA cross-sectional study was conducted on 175 women with FI and 19 healthy volunteers. The functional/structural study includedanorectal manometry/endoanal ultrasound. Neurophysiological studies including pudendal nerve terminal motor latency (PNTML) andsensory-evoked-potentials to anal/rectal stimulation (ASEP/RSEP) were conducted on all healthy volunteers and on 2 subgroups of 42and 38 patients, respectively. ResultsThe main conditions associated with FI were childbirth (79.00%) and coloproctological surgery (37.10%). Cleveland score was 11.39± 4.09. Anorectal manometry showed external anal sphincter and internal anal sphincter insufficiency in 82.85% and 44.00%,respectively. Sensitivity to rectal distension was impaired in 27.42%. Endoanal ultrasound showed tears in external anal sphincter(60.57%) and internal anal sphincter disruptions (34.80%). Abnormal anorectal sensory conduction was evidenced through ASEPand RSEP in 63.16% and 50.00% of patients, respectively, alongside reduced activation of brain cortex to anorectal stimulation. Incontrast, PNTML was delayed in only 33.30%. Stools were loose/very loose in 56.70% of patients. ConclusionsPathophysiology of FI in women is mainly associated with mechanical sphincter dysfunctions related to either muscle damage or, to alesser extent, impaired efferent conduction at pudendal nerves. Impaired conduction through afferent anorectal pathways is also veryprevalent in women with FI and may play an important role as a pathophysiological factor and as a potential therapeutic target.

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