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논문 기본 정보

자료유형
학술저널
저자정보
Joon Seong Lee (Institute for Digestive Research Digestive Disease Center Soonchunhyang University College of Medic) Hyun-Sook Kim (Department of Rheumatology Soonchunhyang University College of Medicine Seoul Korea) Jung Rock Moon (Institute for Digestive Research Digestive Disease Center Soonchunhyang University College of Medic) Tom Ryu (Institute for Digestive Research Digestive Disease Center Soonchunhyang University College of Medic) Su Jin Hong (Department of Internal Medicine Soonchunhyang University College of Medicine Bucheon Gyeonggi-do) Young Sin Cho (Division of Gastroenterology Cheonan Hospital Soonchunhyang University College of Medicine Cheonan) Junseok Park (Institute for Digestive Research Digestive Disease Center Soonchunhyang University College of Medic) Tae Hee Lee (Institute for Digestive Research Digestive Disease Center Soonchunhyang University College of Medic)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.26 No.4
발행연도
2020.1
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477 - 485 (9page)

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Background/AimsOur study aims to characterize esophageal motor function; evaluate the relationships among esophagogastroduodenoscopy (EGD), high-resolution manometry (HRM), and 24-hour esophageal multichannel intraluminal impedance monitoring combined with pH-metry (MII-pH); and elucidate the determinants of esophageal symptom perception in South Koreans with systemic sclerosis (SSc). MethodsWe reviewed prospectively collected HRM (n = 46), EGD (n = 41), and MII-pH (n = 37) data from 46 consecutive patients with SSc (42 females; mean age 50.1 years) who underwent esophageal tests between June 2013 and September 2018. ResultsThe most common HRM diagnosis was normal (39.1%), followed by ineffective esophageal motility (23.9%) and absent contractility (21.7%). Erosive esophagitis was observed in 12.2% of total SSc patients, with a higher frequency in patients with absent contractility than those with normal motility (44.5% vs 0.0%, P = 0.01). Pathologic acid exposure was observed in 6 patients (20.0%) and positive symptom association in 18 patients (60.0%) in MII-pH tests of symptomatic patients. The proportion of SSc patients with esophageal symptoms not explained by reflux or mucosal or motor esophageal abnormalities was 33.0%. ConclusionsEsophageal involvement among South Koreans with SSc was characterized by heterogeneous motility patterns, with a higher prevalence of normal motility and lower prevalence of erosive esophagitis. Reflux hypersensitivity or functional heartburn might be partly attributed to the perception of esophageal symptoms in SSc patients who have neither gastroesophageal reflux disease nor esophageal dysmotility.
#Diagnosis #Esophageal motility disorders #Esophagus #Manometry #Scleroderma

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참고문헌 (38)

참고문헌 신청
Chifflot H / 2008 / Incidence and prevalence of systemic sclerosis : a systematic literature review / Semin Arthritis Rheum 37:223~235.2 google schola Tamaki T / 1991 / Epidemiological study of patients with systemic sclerosis in Tokyo / Arch Dermatol Res 283:366~371 google schola Kang GW / 2018 / Incidence, prevalence, mortality and causes of death in systemic sclerosis in Korea : a nationwide populationbased study / Br J Dermatol 178:e37~e39 google schola Al-Sheikh H / 2019 / Ethnic variations in systemic sclerosis disease manifestations, internal organ involvement, and mortality / J Rheumatol 46:1103~1108 google schola Denaxas K / 2018 / Evaluation and management of esophageal manifestations in systemic sclerosis / Ann Gastroenterol 31:165~170 google schola

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